WARF: P05147US



Hector DeLuca, Lori Plum, Rafal Barycki, Margaret Clagett-Dame

The Wisconsin Alumni Research Foundation (WARF) is seeking commercial partners interested in developing a new vitamin D analog.
OVERVIEWVitamin D is a highly potent regulator of calcium homeostasis and plays an established role in cellular differentiation. A recently discovered class of vitamin D analogs, the 19-nor-vitamin D compounds, shows a selective activity profile with high potency in inducing cellular differentiation and very low calcium mobilizing activity. These features make the 19-nor compounds potentially useful as therapeutic agents for a number of disorders.
THE INVENTIONUW-Madison researchers have developed a new vitamin D analog, 2-methylene-18,19-dinor-1α-hydroxy-homopregnacalciferol. This compound, a 2-methylene-18,19-dinor vitamin D analog, is characterized by a hydroxyl group at carbon 1, a methylene substituent at carbon 2, a hydrogen at carbon 18 and the elimination of carbons 23,24,25,26 and 27.

Compared to 1α,25-dihydroxyvitamin D3, the new analog exhibits relatively high binding to vitamin D receptors, very low intestinal calcium transport activity, and very low ability to mobilize calcium from bone. It also displays relatively high cell differentiation activity, making it potentially useful as an anti-cancer agent or a therapeutic agent for treating skin conditions.
  • Potential anti-cancer agent, especially for use against leukemia, colon, breast and prostate cancers
  • Preventing or treating obesity and reduce body fat
  • Treating skin diseases, such as psoriasis, as well as skin conditions such as wrinkles, slack skin, dry skin and insufficient sebum secretion
  • Potential for treating immune disorders in humans, including multiple sclerosis, lupus, diabetes mellitus, host-versus-graft reaction, and organ transplant rejection
  • Prospective treatment for inflammatory diseases such as rheumatoid arthritis, asthma and inflammatory bowel diseases
  • Promising treatment for renal osteodystrophy
  • Treating other disorders, including acne, alopecia and hypertension
For More Information About the Inventors
Contact Information
For current licensing status, please contact Rafael Diaz at or 608-960-9847.
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