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WARF: P07220US

Calcitonin and Calcitonin-Like Compounds for Multiple Sclerosis


INVENTORS -

Hector DeLuca, Terrence Meehan, Bryan Becklund, Margaret Clagett-Dame

The Wisconsin Alumni Research Foundation (WARF) is seeking commercial partners interested in developing a new method of preventing or treating multiple sclerosis.
OVERVIEWMultiple sclerosis (MS) is a complex and unpredictable disease of the central nervous system.  MS is thought to be an autoimmune disease in which the immune system attacks and destroys the myelin that insulates the nerves in the brain and spinal cord.  When myelin is damaged, the transmission of messages between the brain, spinal cord and body is slowed or blocked, leading to diminished or lost function.

No cure for MS has been developed.  Several therapies, including anti-inflammatory steroids, naturally occurring antiviral proteins known as interferons and immunosuppressive agents, have shown some promise for the treatment of MS symptoms.  However, these treatments are associated with adverse side effects and are not effective for all patients. 

The hormonally active form of vitamin D, 1,25 dihydroxyvitamin D3,  known as calcitriol, has shown some ability to prevent experimental autoimmune encephalomyelitis (EAE) in mice, a chronic relapsing brain and spinal cord disease that resembles MS.  While promising, the concentrations of calcitriol required to achieve this therapeutic effect are likely to cause dose-limiting hypercalcemia and are not suitable for long-term use. Promising research is underway with several analogs of calcitriol that show efficacy in the EAE mouse model and the ability to minimize dose-limiting hypercalcemia, but more work needs to be conducted to determine the potential utility of these analogs in humans.

Another promising alternative is calcitonin and related calcitonin-like compounds.  Calcitonin has been shown to have anti-inflammatory properties in several animal models and may be useful in the treatment of the autoimmune disease rheumatoid arthritis.  In addition, calcitonin can be used to treat hypercalcemia and, as such, may play a role as an adjuvant treatment with vitamin D analogs or other MS treatments.
THE INVENTIONUW-Madison researchers have developed methods of preventing and treating MS by administering synthetic calcitonin, calcitonin-like peptides or calcitonin mimetics to a patient to diminish MS symptoms.  Vitamin D analogs can be administered in combination with the calcitonin to further reduce symptoms. 
BUSINESS OPPORTUNITY
  • Cure for MS is a large and unmet medical need.
  • More than 350,000 individuals in the U.S. are affected.
  • 200 new cases are diagnosed each week.
  • Annual cost of MS in the U.S. is in the billions of dollars.
APPLICATIONS
  • Prevention and treatment of MS
KEY BENEFITS
  • The combination of calcitonin and vitamin D provides improved effectiveness without the danger of hypercalcemia.
  • The use of synthetic calcitonin, calcitonin-like peptides or calcitonin mimetics reduces the likelihood that a patient will develop resistance to treatment during long-term use.
  • Calcitonin and vitamin D should be synergistic because they function by different mechanisms and at different sites. 
STAGE OF DEVELOPMENTEarly stage – in vivo animal data available in EAE murine model.
Contact Information
For current licensing status, please contact John Nagel at jnagel@warf.org or 608-960-9848.
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