WARF: P00032US

Hematopoietic Differentiation of Human Embryonic Stem Cells


James Thomson, Dan Kaufman

The Wisconsin Alumni Research Foundation (WARF) is seeking commercial partners interested in developing a method for creating hematopoietic cells from human embryonic stem cells.
OVERVIEWHematopoietic cells form blood and immune cells and can potentially be used in the treatment of many diseases. Attempts have been made to differentiate mouse embryonic stem cells (ES cells) into hematopoietic cells, but a method for differentiating human ES cells into hematopoietic cells is needed.
THE INVENTIONUW-Madison researchers have developed a method for creating hematopoietic cells from human embryonic stem cells. To create hematopoietic cells, a human ES cell culture is exposed to mammalian hematopoietic stromal cells. At least some of the resulting cells are CD34+ (a standard marker for hematopoietic cells), or can form hematopoietic cell colony-forming units in methylcellulose culture, indicating that the cells are capable of further differentiation.
The hematopoietic cells can potentially be transplanted into a patient along with other MHC-compatible human cells, such as pancreatic islets to treat diabetes. Transplanting hematopoietic cells with other MHC-compatible cells improves the acceptance of the other cells.
  • Obtaining a wide variety of hematopoietic cells, including lymphocyte precursors, B cells, T cells and macrophages, among others
  • Allows the creation of cell cultures for transplantation, transfusion or other uses
  • Co-transplantation of hematopoietic cells with other tissues should result in fewer immune and autoimmune rejection problems than conventional methods.
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For current licensing status, please contact Andy DeTienne at or 608-960-9857.
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