Wisconsin Alumni Research Foundation

Drug Delivery
Drug Delivery
Unimolecular Nanoparticles For Efficient Delivery Of Therapeutic Cationic Peptides
WARF: P170128US02

Inventors: Shaoqin Gong, Wei Xu, Yuyuan Wang, Fabao Liu

The Invention
Provided herein are peptides comprising an amino acid sequence having at least about 85% sequence identity to RYRPRAPIIAVT (SEQ ID NO: 1). These cationic peptides inhibit PKM2 methylation and may be used in the treatment of breast cancer and other diseases or conditions in which PKM2 is overexpressed. Such PKM2 peptides may be delivered to cancer cells using pH sensitive unimolecular nanoparticles comprising anionic polymers.
Additional Information
For More Information About the Inventors
For current licensing status, please contact Rafael Diaz at [javascript protected email address] or 608-960-9847