Human Pluripotent Stem Cell-Derived Brain Organoids For Cancer Modeling And Drug Screening
Inventors: William Murphy, Elizabeth Aisenbrey, Elizabeth Torr, Victoria Harms, Gaurav Kaushik
The present invention relates to substantially planar vascularized brain cancer organoid and methods of using such vascularized brain cancer organoids in anti-cancer drug discovery screen. In particular, provided herein are methods of producing and using complex, highly uniform vascularized brain cancer organoids that comprise physiologically relevant human cells and have the high degree of sample uniformity and reproducibility required for use in high-throughput screening applications.
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