Wisconsin Alumni Research Foundation

Drug Delivery
Drug Delivery
Kras Conditional Knockout Allele
WARF: P210181US01

Inventors: Jing Zhang

The Wisconsin Alumni Research Foundation (WARF) is seeking commercial partners interested in a mouse model for studying cancer.
Differentiation of normal stem cells into the correct cell lineage is a tightly controlled process that involves cell-cell and cell-extracellular matrix interactions as well as signaling through cellular receptors. When this process is disrupted, cell division may occur rather than differentiation leading to tumor formation. Studying gene expression patterns in tumor cells provides potential genetic causes for the uncontrolled cell division. Using these genes, researchers can mimic the genetic triggers in cultured cells creating research tools for studying cancer.
The Invention
A UW-Madison researcher has developed a mouse model for studying cancer in which the gene encoding Kras, a gene associated with cancer, can be knocked out conditionally. The researcher flanked the gene with LoxP sites, so upon expression of Cre recombinase, gene expression is knocked out. The researcher has both the gene construct and Kras knockout mice.
  • Conditionally knock out Kras in mice using the Cre-Lox system
  • Research tools companies could sell the mice or gene construct.
  • Cancer drug screening programs
Key Benefits
  • Allows for tissue/cell specific knockout of Kras, which plays an important role in development and cancer biology
  • Could serve as a control for developing Kras-specific or oncogenic Kras-specific reagents
Additional Information
For More Information About the Inventors
For current licensing status, please contact Jennifer Gottwald at [javascript protected email address] or 608-960-9854