Animals, Agriculture & Food
Inventors: David Lewis, Michael Caldwell
Warfarin is a “first-generation” anticoagulant that has been widely used as a multiple feeding rodenticide for more than 60 years. The prolonged use of warfarin as a rodenticide has, according to some accounts, led to the evolution of warfarin-resistant rodents. More powerful “second-generation” anticoagulant rodenticides were developed and introduced to combat resistance and kill rodents with a single feeding, but there are environmental concerns due to inadvertent poisoning larger predatory animals that ingest poisoned rodents. Recent EPA restrictions on rodenticides using second-generation anticoagulants have created a need for more potent first generation anticoagulants, i.e. warfarin. There is a great need specifically for new compounds that can be paired with first generation poisons to give enhanced rodenticide qualities that can kill rodents in a single feeding.
Researchers at UW-Eau Claire and Marshfield Clinic have developed a new class of compounds that enhance the anticoagulant activity of warfarin when co-administered. When the compound is paired with warfarin, they quadruple the anticoagulant activity when compared to warfarin alone. Additionally, preliminary animal tests show the compounds are not toxic when administered alone.
- As a synergistic rodenticide with warfarin
- Increases warfarin anticoagulant activity by up to 4x
- Non-toxic when administered without warfarin
- Likely not classified as a pesticide by the EPA
Stage of Development