WARF: P05078US02

Early Detection of Hemangiosarcoma and Angiosarcoma


Stuart Helfand, Jaime Modiano

The Wisconsin Alumni Research Foundation (WARF) is seeking commercial partners interested in developing a simple, sensitive and specific test for detecting hemangiosarcoma in its early stages in dogs at risk.
OVERVIEWOf the approximately 65 million domestic dogs in the United States, between 1.5 and 2.5 million will contract canine hemangiosarcoma, an incurable tumor of the cells that line blood vessels. Death usually results from acute internal hemorrhage following rupture of the tumor. Treatment is ineffective because the disease is diagnosed at a late stage when tumors are resistant to chemotherapy, and no method of early diagnosis currently exists.
THE INVENTIONUW-Madison researchers have developed a simple, sensitive and specific test for detecting hemangiosarcoma in its early stages in dogs at risk. The inventors discovered that the “primitive” endothelial cells associated with hemangiosarcoma or angiosarcoma, a similar tumor that affects humans, express a specific combination of proteins on their surface. To diagnose hemangiosarcoma or angiosarcoma, multiparameter flow cytometry can be used to detect cells that express these proteins.
  • Early detction of hemangiosarcoma and related cancers
  • Provides a method of detecting hemangiosarcoma at an early stage, when treatments may be more effective
  • Enables early diagnosis of angiosarcoma in people at high risk
  • Minimally invasive—diagnosis is made using a blood sample rather than a biopsy
  • Capable of distinguishing between hemangiosarcoma/angiosarcoma and benign proliferative lesions, such as hemangioma or hematoma
  • Can distinguish between hemangiosarcoma/angiosarcoma and leukemia/lymphoma, allowing treatments to be tailored to the particular disease
Contact Information
For current licensing status, please contact Jennifer Gottwald at or 608-960-9854.
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Since its founding in 1925 as the patenting and licensing organization for the University of Wisconsin-Madison, WARF has been working with business and industry to transform university research into products that benefit society. WARF intellectual property managers and licensing staff members are leaders in the field of university-based technology transfer. They are familiar with the intricacies of patenting, have worked with researchers in relevant disciplines, understand industries and markets, and have negotiated innovative licensing strategies to meet the individual needs of business clients.