Analytical Instrumentation, Methods & Materials
KITS AND METHODS FOR SUPER-RESOLUTION MICROSCOPY
Inventors: Aussie Suzuki, Mark Burkard, Roshan Norman, Emma Recchia
UW Madison Researchers have improved upon conventional expanded microscopy. They have developed novel 4-fold and a 12-fold mExM (modified expansion microscopy) methodologies, which stably and reproducibly expand a specimen. The new mExM methods can achieve ~5 nm accuracy with super-resolution microscopes and ~20 nm accuracy with regular wide-field microscopes. The technology is designed as a kit for mExM. The kit includes a chemically and biochemically inert mold and instructions for use of the mold in an mExM method.