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100 Results for 'Pluripotent Stem Cells'
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Technology
Methods for Generating Cardiac Fibroblasts
UW-Madison researchers have developed a defined and efficient method to direct the differentiation of epicardial cells to produce cardiac fibroblast cells. This builds on Dr. Palacek’s prior inn...
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Sean Palecek, Martha Floy | P210258US02
Technology
CHEMICAL COCKTAIL FOR INDUCING SENESCENCE IN HUMAN NEURONS TO PROMOTE DISEASE MODELING AND DRUG DISCOVERY
Provided herein are methods and compositions for inducing chemical senescence in neurons and methods of using chemically induced senescent neurons for modeling neurodegenerative disease and drug disco...
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Su-Chun Zhang, Ali Fathi | P200006US02
Technology
METHODS FOR CONTROLLED INDUCTION OF BIOENGINEERED NEUROEPITHELIAL TISSUES AND 3-D NEUROEPITHELIAL TUBES
Described herein are methods, compositions, and kits for directed differentiation of human pluripotent stem cells, neuromesodermal progenitors, and neural stem cells into bioengineered elliptical neur...
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Randolph Ashton, Gavin Knight, Benjamin Knudsen, Nisha Iyer, Carlos Marti-Figueroa | P200307US03
Technology
GENERATION OF NOREPINEPHRINE NEURONS FROM HUMAN STEM CELLS
Methods for obtaining populations of norepinephrine (NE) neuronal progenitor cells and creating enriched populations of NE neurons are provided herein. Also provided herein are methods for obtaining g...
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Su-Chun Zhang, Yunlong Tao | P200364US02
Technology
Functional Neutrophils from Induced Pluripotent Stem Cells
Despite recent advances in prevention and management, myelosuppression and febrile neutropenia are a complication of cancer therapies and a common cause of morbidity and mortality, especially in pedia...
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Igor Slukvin, Vera Brok Volchanskaya, Kran Suknuntha, Anna Huttenlocher, David Bennin, Lucas Klemm | P190225US03
Technology
GENERATION OF HOXA-EXPRESSING HEMOGENIC ENDOTHELIUM WITH ENHANCED T CELL POTENTIAL FROM HPSCS
The present invention provides methods of creating a population of hemogenic endothelial cells with arterial specification and enhanced T cell potential. The methods involve inducing the expression of...
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Igor Slukvin, Ho Sun Jung | P200133US02
Technology
Induced Pluripotent Stem Cell Lines for Down Syndrome Research
Down syndrome (Trisomy 21, Ts21) is a condition caused by having an extra copy of the 21st chromosome due to an error in cell division. People born with Down syndrome have a characteristic phenotype a...
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Anita Bhattacharyya Consigny, Su-Chun Zhang | P160139US01
Technology
Generating Arterial Endothelial Cell-Seeded Vascular Grafts
A frequent procedure in cardiovascular surgery is to replace or bypass a blood vessel in order to provide a more adequate flow of blood to downstream tissues. In operations that bypass coronary arteri...
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James Thomson, Jue Zhang, John Maufort | P180255US02
Technology
Methods For Cardiac Fibroblast Differentiation of Human Pluripotent Stem Cells
Cardiac fibroblasts (CF) comprise a major fraction of the total cells in the heart and can arise from mesodermal progenitor cells as the heart develops. CFs are primarily responsible for generating ex...
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Timothy Kamp, Jianhua Zhang | P160319US02
Technology
Method Of In Vitro Differentiation Of Neural Stem Cells, Motor Neurons And Dopamine Neurons From Pri
A method of differentiating embryonic stem cells into ventral spinal progenitor cells is disclosed. In one embodiment, the invention comprises culturing a population of cells comprising a majority of ...
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Su-Chun Zhang, Xue-jun Li | P07445US
Technology
SOMATIC CELL REPROGRAMMING
The present invention relates to methods for reprogramming a somatic cell to pluripotency by administering into the somatic cell at least one or a plurality of potency-determining factors. The inventi...
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James Thomson, Junying Yu | P08167US
Technology
Feeder Independent Extended Culture Of Embryonic Stem Cells
Previous methods for culturing human embryonic stem cells have required either fibroblast feeder cells or a medium which has been exposed to fibroblast feeder cells in order to maintain the stem cells...
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James Thomson, Ren-He Xu | W04001US
Technology
MYELOPOISIS FROM STEM CELLS
A method for efficient generation of neutrophils, eosinophils, macrophages, osteoclasts, dendritic cells an Langerhans cells from human embryonic stem cells is disclosed.
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Igor Slukvin, Maksym Vodyanyk, Kyung-Dal Choi | P09078US02
Technology
PLURIPOTENT STEM CELLS OBTAINED BY NON-VIRAL REPROGRAMMING
Methods for reprogramming primate somatic cells to pluripotency using an episomal vector that does not encode an infectious virus are disclosed. Pluripotent cells produced in the methods are also disc...
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James Thomson, Junying Yu | P09113US02
Technology
In Vitro Model Of Spinal Muscular Atrophy
A population of iPS cells derived from somatic cells from a spinal muscular atrophy patient is disclosed. In one embodiment of the invention, the cells have been cultured to produce neural cells. In a...
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Clive Svendsen, Allison Ebert | P09194US02
Technology
GENERATION OF CLONAL MESENCHYMAL PROGENITORS AND MESENCHYMAL STEM CELL LINES UNDER SERUM-FREE CONDITIONS
Methods for obtaining multipotent mesenchymal stem cells under serum-free conditions and methods for identifying multipotent mesenchymal progenitor cells are disclosed.
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Igor Slukvin, Maksym Vodyanyk, Junying Yu, James Thomson | P07264US
Technology
Oct4 And Sox2 With Sv40 T Antigen Produce Pluripotent Stem Cells From Primate Somatic Cells
Methods for reprogramming primate somatic cells to pluripotency using an episomal vector that does not encode an infectious virus are disclosed. Pluripotent cells produced in the methods are also disc...
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James Thomson, Junying Yu | P09113US04
Technology
MEDIUM CONTAINING PIPECHOLIC ACID AND GAMMA AMINO ACID AND CULTURE OF EMBRYONIC STEM CELLS
Previous methods for culturing primate pluripotent stem cells have required either fibroblast feeder cells or a medium which was exposed to fibroblast feeder cells to maintain the stem cells in an und...
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Tenneille Ludwig, James Thomson | P09119US
Technology
METHOD FOR CULTURING STEM CELLS
A three-dimensional microwell system that supports long term pluripotent cell culture and formation of homogeneous embryoid bodies (EBs) is described. Microwell-cultured pluripotent cells remain viabl...
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Timothy Kamp, Jianhua Zhang, Jeffrey Mohr, Juan DePablo, Sean Palecek | P08310US02
Technology
MEDIUM CONTAINING PIPECHOLIC ACID AND GAMMA AMINO BUTYRIC ACID AND CULTURE OF EMBRYONIC STEM CELLS
Previous methods for culturing human embryonic stem cells have required either fibroblast feeder cells or a medium which has been exposed to fibroblast feeder cells in order to maintain the stem cells...
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Tenneille Ludwig, James Thomson | P04124US
Technology
Methods Of Maintaining, Expanding, And Differentiating Neuronal Subtype Specific Progenitors
Methods for expanding proliferating populations of neuronal subtype-specific progenitors and creating substantially pure populations of motor neurons are provided herein. In particular, the present in...
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Su-Chun Zhang, Zhong-wei Du | P150190US02
Technology
Inorganic Coatings For The Enhancement Of Chemical Transfection
Disclosed are methods for cell transfection and regulating cellular behavior. More particularly, the present disclosure relates to methods of non-viral cell transfection and regulating cellular behavi...
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William Murphy, Andrew Khalil, Xiaohua Yu, Krishanu Saha, Jared Carlson-Stevermer, Benjamin Steyer | P150078US01
Technology
Simplified Basic Media For Human Pluripotent Cells
Fully defined media that support pluripotent cell viability, proliferation, cloning, and derivation, as well as methods and compositions including these media are described. Methods for deriving iPS c...
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James Thomson, Guokai Chen | P120133US01
Technology
Anti-Inflammatory Macrophages And Uses Thereof
The invention relates to a purified, novel anti-inflammatory population of macrophage and methods of making and using such macrophage.
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Peiman Hematti, Jaehyup Kim | P09357US02
Technology
Substantially Pure Human Retinal Progenitor, Forebrain Progenitor, And Retinal Pigment Epithelium Cell Cultures And Methods Of Making The Same
Methods for producing substantially pure cultures of human neural retinal progenitor cells, forebrain progenitor cells, and retinal pigment epithelial cells are disclosed. In addition, the successful ...
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David Gamm, Jason Meyer | P09273US02