Wisconsin Alumni Research Foundation

Technology

STEM CELL FATE ENGINEERING METHODS

UW-Madison researchers have developed a simple and versatile method to spatially pattern hPSC differentiations via localized adsorption of morphogens on substrates. Morphogens including BMP4, noggin, ...
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Sean Palecek, Gyuhyung Jin | P210249US02

Technology

CARDIAC FIBROBLAST DERIVED EXTRACELLULAR MATRIX

UW-Madison researchers have discovered a novel marker in cardiac fibroblasts and myofibroblasts that reliably predicts extracellular matrix production in cultured cardiac fibroblasts. Sushi Domain Con...
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Eric Schmuck, Amish Raval, Sushmita Roy, Tianhua Zhou | P210363US02

Technology

Methods for Generating Cardiac Fibroblasts

UW-Madison researchers have developed a defined and efficient method to direct the differentiation of epicardial cells to produce cardiac fibroblast cells. This builds on Dr. Palacek’s prior inn...
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Sean Palecek, Martha Floy | P210258US02

Technology

Functional Neutrophils from Induced Pluripotent Stem Cells

Despite recent advances in prevention and management, myelosuppression and febrile neutropenia are a complication of cancer therapies and a common cause of morbidity and mortality, especially in pedia...
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Igor Slukvin, Vera Brok Volchanskaya, Kran Suknuntha, Anna Huttenlocher, David Bennin, Lucas Klemm | P190225US03

Technology

SOMATIC CELL REPROGRAMMING

The present invention relates to methods for reprogramming a somatic cell to pluripotency by administering into the somatic cell at least one or a plurality of potency-determining factors. The inventi...
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James Thomson, Junying Yu | P08167US

Technology

MYELOPOISIS FROM STEM CELLS

A method for efficient generation of neutrophils, eosinophils, macrophages, osteoclasts, dendritic cells an Langerhans cells from human embryonic stem cells is disclosed.
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Igor Slukvin, Maksym Vodyanyk, Kyung-Dal Choi | P09078US02

Technology

In Vitro Model Of Spinal Muscular Atrophy

A population of iPS cells derived from somatic cells from a spinal muscular atrophy patient is disclosed. In one embodiment of the invention, the cells have been cultured to produce neural cells. In a...
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Clive Svendsen, Allison Ebert | P09194US02

Technology

METHOD FOR CULTURING STEM CELLS

A three-dimensional microwell system that supports long term pluripotent cell culture and formation of homogeneous embryoid bodies (EBs) is described. Microwell-cultured pluripotent cells remain viabl...
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Timothy Kamp, Jianhua Zhang, Jeffrey Mohr, Juan DePablo, Sean Palecek | P08310US02

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