Wisconsin Alumni Research Foundation

Technology

Methods for Generating Cardiac Fibroblasts

UW-Madison researchers have developed a defined and efficient method to direct the differentiation of epicardial cells to produce cardiac fibroblast cells. This builds on Dr. Palacek’s prior inn...
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Sean Palecek, Martha Floy | P210258US02

Technology

Functional Neutrophils from Induced Pluripotent Stem Cells

Despite recent advances in prevention and management, myelosuppression and febrile neutropenia are a complication of cancer therapies and a common cause of morbidity and mortality, especially in pedia...
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Igor Slukvin, Vera Brok Volchanskaya, Kran Suknuntha, Anna Huttenlocher, David Bennin, Lucas Klemm | P190225US03

Technology

SOMATIC CELL REPROGRAMMING

The present invention relates to methods for reprogramming a somatic cell to pluripotency by administering into the somatic cell at least one or a plurality of potency-determining factors. The inventi...
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James Thomson, Junying Yu | P08167US

Technology

MYELOPOISIS FROM STEM CELLS

A method for efficient generation of neutrophils, eosinophils, macrophages, osteoclasts, dendritic cells an Langerhans cells from human embryonic stem cells is disclosed.
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Igor Slukvin, Maksym Vodyanyk, Kyung-Dal Choi | P09078US02

Technology

In Vitro Model Of Spinal Muscular Atrophy

A population of iPS cells derived from somatic cells from a spinal muscular atrophy patient is disclosed. In one embodiment of the invention, the cells have been cultured to produce neural cells. In a...
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Clive Svendsen, Allison Ebert | P09194US02

Technology

METHOD FOR CULTURING STEM CELLS

A three-dimensional microwell system that supports long term pluripotent cell culture and formation of homogeneous embryoid bodies (EBs) is described. Microwell-cultured pluripotent cells remain viabl...
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Timothy Kamp, Jianhua Zhang, Jeffrey Mohr, Juan DePablo, Sean Palecek | P08310US02

Technology

Inorganic Coatings For The Enhancement Of Chemical Transfection

Disclosed are methods for cell transfection and regulating cellular behavior. More particularly, the present disclosure relates to methods of non-viral cell transfection and regulating cellular behavi...
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William Murphy, Andrew Khalil, Xiaohua Yu, Krishanu Saha, Jared Carlson-Stevermer, Benjamin Steyer | P150078US01

Technology

Simplified Basic Media For Human Pluripotent Cells

Fully defined media that support pluripotent cell viability, proliferation, cloning, and derivation, as well as methods and compositions including these media are described. Methods for deriving iPS c...
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James Thomson, Guokai Chen | P120133US01

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