Therapeutics & Vaccines
GENERATION OF INDUCED NEUTROPHILS WITH INCREASED ACTIVATION AND TRANSMIGRATION CAPABILITIES
WARF: P240375US02
Inventors: Anna Huttenlocher, David Bennin, Frances Smith
The Invention
UW-Madison researchers have discovered that MYDGF-knockout iNeutrophils (neutrophils produced through differentiation from pluripotent stem cells) have the ability to efficiently migrate across endothelium in response to bacteria. MYDGF-knockout iNeutrophils also show a more activated phenotype with aggregation, increased ROS production and other antimicrobial effector functions. The MYDGF-knockout iNeutrophils exhibit better activity than any similar line. Accordingly, the use of MYDGF-knockout PSCs is recommended for the production of robust iNeutrophils.
Additional Information
For More Information About the Inventors
Tech Fields
For current licensing status, please contact Andy DeTienne at [javascript protected email address] or 608-960-9857