Pluripotent Stem Cells
SIRPα Knockout iPSC-derived and CAR-comprising Macrophages with Enhanced Anti-tumor Activity
WARF: P250102US03
Inventors: Igor Slukvin, Portia Smith, Jue Zhang
The Invention
UW-Madison researchers have discovered new uses for macrophages produced without SIRPα. SIRPα is a ligand for the ubiquitously expressed “don’t-eat-me” signal molecule CD47. The inventors discovered that SIRPα-KO i-Macs are resistant to ‘macrophage exhaustion’, which is the property reported by others that the antibody-dependent phagocytic activity of macrophages falls off over time, even if re-exposed to the target agent. No resistant macrophage has been reported to date. SIRPα-KO i-Macs keep going, through 120 hours at least, and the researchers see renewed activity if they resupply Abs.
Additional Information
For More Information About the Inventors
Tech Fields
For current licensing status, please contact Andy DeTienne at [javascript protected email address] or 608-960-9857