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338 Results for 'Research Tools'
PAGE 4 OF 14
Technology
UNIVERSAL METHOD FOR PARASITE AND EUKARYOTIC ENDOSYMBIONT IDENTIFICATION
UW-Madison researchers have developed and validated a novel “parasitome” method to accurately characterize parasites in samples. Like published metabarcoding protocols, the new method consists of ...
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Tony Goldberg, Leah Owens | P220194WO01
Technology
ENGINEERED TRYPTOPHAN DECARBOXYLASES AND USES THEREOF FOR SYNTHESIZING TRYPTAMINE ANALOGS
UW-Madison researchers have identified several tryptophan decarboxylase (TDC) mutations for improving enzymatic activity towards substituted tryptamines. Having identified these mutations, the researc...
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Andrew Buller, Allwin McDonald | P220120US02
Technology
Characterization Via Homologizing Disparate Speech Terminology
Aspects of the present disclosure from UW Madison researchers are directed to methods and apparatuses involving characterization via homologizing disparate speech terminology. As may be implemented in...
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Joao Ricardo Reboucas Dorea, Rafael Ferreira | P200128WO01
Technology
SITE-SELECTIVE DEUTERATION OF AMINO ACIDS THROUGH DUAL PROTEIN CATALYSIS
UW-Madison researchers have developed a protein-based method for selective deuteration of amino acids. The inventors’ method leverages the aminotransferase DsaD, a PLP-dependent enzyme, and a small ...
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Andrew Buller, Tyler Doyon | P220181US02
Technology
METHODS OF DESIGNING PRODUCTION OF MICROBIAL COMMUNITIES, METHODS OF PRODUCING MICROBIAL COMMUNITIES, AND MICROBIAL COMMUNITIES PRODUCED THEREBY
UW-Madison researchers disclose an improved method for generating diverse microbiomes. The method leverages growth media composition and species inoculum ratios to control the makeup of the consortia,...
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Ophelia Venturelli, Bryce Connors, Brian Pfleger | P220011WO01
Technology
FAST, EASY, AND DIRECT AZIDYLATION OF BIOMOLECULES IN SOLUTION
UW-Madison researchers have developed a simple method for directly and rapidly attaching azide (N3) groups to proteins in solution, using widely available solvents, to produce covalently modified azid...
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Michael Sussman, Benjamin Minkoff, Jamison Wolfer, Heather Burch | P220072WO01
Technology
VACO6
A UW-Madison researcher has established a cell line, called VACO6, from a discarded tissue specimen of a surgically resected primary human colon cancer. The detailed characteristics of the clinical do...
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James Willson | P230180US01
Technology
PHOTO-CLEAVABLE SURFACTANTS
UW-Madison researchers have developed photo-cleavable anionic surfactants, particularly 4-hexylphenylazosulfonate (Azo) and sodium 4-hexylphenylazosulfonate derivatives, which can be rapidly degraded ...
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Ying Ge, Song Jin, Tania Guardado Alvarez, Kyle Brown | P180335US03
Technology
RHESUS MACAQUE INDUCED PLURIPOTENT STEM CELL (IPSC) LINE: LINE Rh2431
A UW-Madison researcher has developed a Rhesus Macaque induced pluripotent stem cell (iPSC) line, called the Rh2431 iPSC line.
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John Maufort | P230112US01
Technology
UW-Madison researchers have developed a titin DNA construct (a ‘titin minigene plasmid’) that is useful for identifying agents that modulate the titin size reduction that correlates with age and l...
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Wei Guo, Yanghai Zhang | P230097US01
Technology
CYNOMOLGUS MACAQUE INDUCED PLURIPOTENT STEM CELL (IPSC) LINE: LINE cy0657
A UW-Madison researcher has developed a Cynomolgus Macaque induced pluripotent stem cell (iPSC) line, called the cy0657 iPSC line.
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John Maufort | P230113US01
Technology
METHOD FOR DIFFERENTIATION OF BRAIN MURAL CELLS FROM HUMAN PLURIPOTENT STEM CELLS
UW-Madison researchers disclose a new method for differentiating brain mural cells – encompassing pericytes and vascular smooth muscle cells – from hPSCs. The inventors used their previously discl...
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Eric Shusta, Benjamin Gastfriend, Sean Palecek | P220005US02
Technology
Primatized Mouse
The present invention is a novel, primatized mouse model for studying the immune system of nonhuman primates in a relatively low-cost mouse. The UW-Madison inventor used a different source of immune c...
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Matthew Brown | P210237US02
Technology
Organelle-Targeted Genetically-Encoded Voltage Indicators And Methods Of Use Thereof
UW researchers have developed modified genetically encoded plasma membrane voltage probes for monitoring mitochondrial and ER membrane voltage gradients. A fluorescence protein tag was coupled with a ...
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Meyer Jackson, Masoud Sepehri Rad | P210400US02
Technology
ANTI-GATA2 MONOCLONAL ANTIBODIES
UW-Madison researchers have developed three novel monoclonal antibodies that all have exceptional activity against human and mouse GATA2.
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Emery Bresnick, Daniel Matson | P220242US01
Technology
GENERATION OF RABBIT POLYCLONAL ANTIBODY FOR PKM2
A UW-Madison researcher has developed a rabbit polyclonal antibody for methylated PKM2. There are three PKM2 arginine methylation sites R445, R447, R455. The antibody was generated using peptides enco...
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Wei Xu | P220296US01
Technology
GENETIC TOOLS FOR THE ENGINEERING OF BACTEROIDES
UW-Madison researchers have developed a CRISPR-based genome editing tool to study and modify PULs in B. uniformis. The B. uniformis PULs show distinct glycan-degrading functions and transcriptional co...
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Ophelia Venturelli, Jun Feng | P220212US01
Technology
RBM20 ANTIBODY
A UW-Madison researcher has developed and characterized an anti-RBM20 polyclonal antibody rabbit preparation (which he calls the “RBM20 antibody”). The inventor expressed and purified the full len...
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Wei Guo, Marion Greaser | P220238US01
Technology
MANIPULATING BACTEROIDES COLONIZATION OF MAMMALIAN GUT
UW-Madison researchers disclose two mutant Bacteroides strains, BU ΔPUL18 and BU ΔPUL37, each with characteristics that could be useful in modulating the gut microbiome.
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Ophelia Venturelli, Jun Feng | P220237US01
Technology
Knockout of GFAP In the Mouse (Model tm1Mes)
UW-Madison researchers have developed a GFAP knockout mouse model, designated tm1Mes, that has been engineered to have an internal deletion of the Gfap gene that renders it completely non-functional. ...
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Albee Messing, Maureen McCall | P220164US01
Technology
Mouse Model of Alexander Disease (Model B6.129S7 (Cg) Gfap tm2Mes)
UW-Madison researchers have developed a mouse model of Alexander disease, designated B6.129S7 (Cg) Gfap tm2Mes, that was engineered as a knock-in of the R236H point mutation in the Gfap gene; this is ...
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Albee Messing, Tracy Hagemann | P220167US01
Technology
Mouse Model of Alexander Disease (Model FVB.129S7 (Cg) Gfap tm2Mes)
UW-Madison researchers have developed a mouse model of Alexander disease, designated FVB.129S7 (Cg) Gfap tm2Mes, that was engineered as a knock-in of the R236H point mutation in the Gfap gene; this is...
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Albee Messing, Tracy Hagemann | P220165US01
Technology
Transgenic Mouse Expressing Human GFAP (Model Tg73.7)
UW-Madison researchers have developed a transgenic mouse, designated Tg73.7, that carries full-length copies of a human genomic clone of wild-type GFAP, including all introns and exons.
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Albee Messing, Michael Brenner | P220166US01
Technology
Mouse Model of Alexander Disease (Model FVB.129S7 (Cg) Gfap tm3Mes)
UW-Madison researchers have developed a mouse model of Alexander disease, designated FVB.129S7 (Cg) Gfap tm3Mes, that was engineered as a knock-in of the R76H point mutation in the Gfap gene. This is ...
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Albee Messing, Tracy Hagemann | P220169US01
Technology
A Novel Counter-Selection Marker for Use in Lactic Acid Bacteria
Lactic acid bacteria constitute a large group of Gram-positive bacteria (over 200 species described), of which Lactobacillus is the largest genus in the lactic acid bacteria group. Members of the Lact...
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Jan Peter Van Pijkeren, Jeehwan Oh | P160379US01