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317 Results for 'Research Tools'
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Technology
Designing Programmable Inducible Promoters for Biosensor Applications
Biosensors to detect small molecule ligands (e.g., metabolites) have applications in synthetic biology, medical diagnosis, environmental monitoring, bioremediation and bioenergy. Protein-based biosens...
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Srivatsan Raman, Aseem Ansari, Xiangyang Liu, Jose Rodriguez-Martinez | P170081US02
Technology
Enhanced Biomass Digestion with Wood Wasp Bacteria
Plant biomass represents a vast and renewable source of energy. However, harnessing this energy requires breaking down tough lignin and cellulose cell walls. In nature, certain microbes can deconstruc...
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Cameron Currie, Brian Fox, Taichi Takasuka, Adam Book | P110314US03
Technology
Improved Molecule Mass Detection Using Electron Field Emission from Kinetically Impacted Membranes
Mass spectrometry is a broadly applicable analysis tool for detecting and characterizing molecules and other chemical species, including complex mixtures of biomolecules such as peptides, proteins or ...
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Robert Blick, Lloyd Smith, Michael Westphall, Hua Qin | P09192US
Technology
Microfluidic Device for Rapid Nucleic Acid Isolation and Purification
Extraction and isolation of nucleic acids from biological samples is an essential prerequisite for further amplification, detection and quantification of specific genetic sequences. The first step in ...
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David Beebe, Scott Berry | P100050US01
Technology
Improved Sensor Enables Sensitive Detection of Large Molecules in Mass Spectrometry
Mass spectrometry is a highly selective and quantitative technique that is widely used to determine the chemical composition of a sample. Applications of this analytical tool include measuring isotope...
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Robert Blick, Michael Westphall, Lloyd Smith | P05110US
Technology
Creating ‘Designer’ Yeast Hybrids for Brewing and More
Interspecies yeast hybrids are critical for producing commercially important fermentation products such as Belgian ale, certain ciders and cold-fermented wines. As one major example, lager beer, the m...
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Christopher Hittinger, David Peris Navarro, William Alexander | P160107US03
Technology
Reagents for Bioreversible Protein Esterification
Chemoselective transformations are of key importance in modern chemical biology. Protein esterification can, for example, be employed for labeling, enhanced cellular uptake and other useful protein mo...
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Ronald Raines, Kalie Mix | P150262US03
Technology
Titin Minigene: Cardiac Research Tool
Titin is a sarcomeric protein expressed primarily in striated muscles. It is responsible for maintaining the structure and biomechanical properties of muscle cells.
In the heart, cardiac titin under...
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Marion Greaser, Shijun Li, Wei Guo | P170288US01
Technology
Animal Model of Brittle Bone Disease
Osteogenesis imperfecta (OI) or brittle bone disease is an incurable genetic disorder that causes fragile bones and a lifetime of breaks and fractures. Recently, mutations in the gene for bone morphog...
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Daniel Greenspan, Se-Jin Lee | P160036US01
Technology
Zip-Lignin™ Assay: An Analysis and Validation Tool
To produce pulp from wood, harsh chemicals are applied during cooking and bleaching mainly because lignin is tough to break down. To make it easier to degrade, Wisconsin researchers discovered how che...
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John Ralph, Steven Karlen, Fachuang Lu, Dharshana Padmakshan | P150118US02
Technology
Cell Lines for High Throughput Screening of Estrogenic Compounds
Two estrogen receptor isoforms regulate normal mammary cells in response to estrogen: ERα and ERβ. ERα is currently a therapeutic target in breast cancer, and breast cancers expressing ERα are com...
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Wei Xu, John Hawse, Frank Secreto | P150257US01
Technology
Bioluminescent Influenza Virions for High Throughput Screening
Assays currently used to detect neutralizing antibodies to influenza virus or measure virion binding to cells, antibodies or receptors require multiple steps. These steps are destructive, low sensitiv...
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Andrew Mehle | P160304US01
Technology
Yeast-Based Intein Platform for Drug Production
The therapeutic and biochemical properties of proteins including antibodies can be enhanced by custom chemical functionalization that enables modifications, such as small molecule drug conjugation, PE...
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Eric Shusta, Cathryn Marshall | P150056US02
Technology
Small Molecule Catalysts of Oxidative Protein Folding
Approximately 20 percent of human proteins – including many of high pharmaceutical relevance – are believed to contain disulfide bonds critical for proper structure and function. However, producin...
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Ronald Raines, John Lukesh | P150010US02
Technology
Enhancing Cell Penetration to Improve Drug Delivery
The utility of many biologic drugs is limited by inefficient cellular delivery. There is a particular need for methods and reagents that facilitate delivery of peptides and proteins into the interior ...
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Ronald Raines, Kristen Andersen | P150031US02
Technology
New Influenza B Virus Enables Real-Time Tracking of Disease Progression
Influenza infections in humans, from the common seasonal flu to the deadly pandemics of the 20th century, are caused chiefly by influenza A and influenza B viruses. Understanding the in vivo dynamics ...
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Andrew Mehle | P160032US01
Technology
Enhanced Endotoxin Detection: New Advantages in Liquid Crystal Assays for Gram-Negative Pathogens
Gram-negative bacterial infections are an ongoing challenge to health care providers worldwide. Detection, treatment and control of such pathogens have gained increasing importance in the context of a...
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Nicholas Abbott, Abhijit Dan | P160072WO01
Technology
Bovine Macrophage Cell Line
Macrophages are white blood cells that ingest foreign material and play a crucial role in the immune system. Presently, there is no bovine macrophage cell line available for research and testing purpo...
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Charles Czuprynski, Dhammika Atapattu, Josely Figueiredo | P140060US01
Technology
Multiphoton Flow Cytometer for High Throughput Analysis of Multicellular Aggregates Like Pancreatic Islets
Regenerative medicine requires a practical, high throughput method of assessing the cellular components of multicellular entities before transplantation. Such a method would have many clinical and res...
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Brenda Ogle, Luis Fernandez, Kevin Eliceiri, Matthew Hanson | P07386US
Technology
New Viral Propagation Method Yields Insight Into Childhood Asthma
In addition to the common cold, human rhinoviruses (RV) trigger nearly half of all cases of asthma exacerbation. Wheezing illnesses in infancy caused by RV are associated with a high risk of developin...
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James Gern, Yury Bochkov, Ann Palmenberg | P140382US02
Technology
Adapted Rhinovirus C for Maximum Virus Yield
Human rhinoviruses (species A, B and C) encompass more than 160 types that are responsible for the majority of upper respiratory tract infections (common colds) and many of the lower respiratory tract...
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James Gern, Yury Bochkov, Ann Palmenberg, Kelly Watters | P160050US02
Technology
Rat Model of Schizophrenia for Research and Preclinical Study
Schizophrenia is a complex neuropsychiatric disease afflicting up to 1 percent of the worldwide population. It affects perception, behavior and thinking and can have devastating social ramifications. ...
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John-Paul Yu, Clifford Rubinstein | P160418US01
Technology
Monomeric Fluorescent Protein-Ligand Complexes with Strong Fluorescence in the Far-Red Region
Fluorescent proteins can be found today in most molecular biology laboratories. Since the discovery of Green Fluorescent Protein (GFP) in the early 1960s, fluorescent molecules have revolutionized man...
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Wayne Schaefer, Ramaswamy Subramanian, Swagatha Ghosh | T150029WO01
Technology
Streamlined Design for Transferring Analytes
Polymerase chain reaction (PCR) is used to generate copies of a particular DNA sequence. The technique is common and indispensable in many research applications. Unfortunately, methods for isolating/p...
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David Beebe, Ben Casavant, David Guckenberger, Scott Berry | P130361US01
Technology
Bio-Based Production of Non-Straight-Chain and Oxygenated Fatty Acids for Fuels and More
Fatty acids generally can be classified as straight-chain or non-straight-chain. Non-straight-chain fatty acids are less abundant and highly valued in dietary supplements, cosmetics, pharmaceuticals, ...
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Timothy Donohue, Rachelle Lemke, Joshua Coon, Amelia Peterson, Michael Westphall | P140318US02