Wisconsin Alumni Research Foundation

Technology

Mouse Model for Mania

Presently, there are no good rodent models for mania, which is a critical component of bipolar disorder. The most commonly used approach is to inject normal mice with amphetamines to produce hyperacti...
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Stephen Gammie | P100188US01

Technology

Computer-Based Determination of Haplotype

Humans are diploid organisms whose (non-sex) cells contain two copies of each chromosome – one from each parent. Each of these two copies may be distinguished by genetic variations such as insertion...
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Tom Anantharaman, Bud Mishra, Will Casey | P05170US

Technology

New Amphiphiles for Manipulating Membrane Proteins

Membrane proteins perform many crucial functions in vivo but are difficult to manipulate and study because they are not soluble in simple aqueous buffers. Solubilizing membrane proteins for physical c...
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Samuel Gellman, Pil Seok Chae | P09028US02

Technology

Influenza Reporter Virus Imaged In Vivo

Currently, it is not possible to visualize the in vivo dynamics of an influenza infection. All existing models rely on proxies to measure viral replication (e.g., viral concentration in nasal washes) ...
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Andrew Mehle | P130288US01

Technology

Phosphine Ligands Made Cheaper, Better

Enantiomers are pairs of compounds that have the same chemical formula but different spatial structures (like your left and right hand, they are non-superimposable mirror images of each other). This i...
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Jennifer Schomaker, Robert Grigg, Ryan Van Hoveln | P130268US02

Technology

Designing Ubiquitin Oligomers

Ubiquitin (Ub) is a small protein composed of 76 amino acids and found throughout the cells of eukaryotic organisms. It folds into a compact globular structure, often as part of a complex of proteins....
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Eric Strieter, Ellen Valkevich, Robert Guenette | P120240US02

Technology

Improved Disulfide-Bond Reducing Agents

Disulfide bonds between cysteine residues are the most common crosslinking agents in proteins. Reducing these bonds is an ordinary procedure in biochemistry and biotechnology. The most commonly used r...
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Ronald Raines, John Lukesh | P110330US02

Technology

New Amphiphiles for Manipulating Integral Membrane Proteins

Integral membrane proteins are crucial cellular components, helping to transfer material and signals through the cytoplasm or between different cell compartments. Analyzing the structures and function...
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Samuel Gellman, Pil Seok Chae, Soren Rasmussen, Brian Kobilka | P110170US02

Technology

DNA Sequencing with Piezoelectric Nanopore

‘Nanopore sequencing’ holds the potential for sequencing a single molecule of DNA without the need for conventional tools like chemical labels or costly optical instruments. This promising...
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Robert Blick, Eric Stava | P130036US01

Technology

Device Uses Air Gap for Easier Fraction Isolation

Isolating analytes from complex biological samples is one of the most crucial steps in many areas of biological research and clinical diagnostics. Paramagnetic particles (PMPs) or beads are important ...
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David Beebe, Scott Berry | P130107US01

Technology

Assembly of Full-Length Genes from DNA Arrays

The ability to chemically synthesize single-stranded oligonucleotides has had a profound impact on research and medicine. Yet existing strategies have their limitations. One critical limitation is the...
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Lloyd Smith, Cheng-Hsien Wu | P120014US02

WARF