Wisconsin Alumni Research Foundation

Technology

Yeast-Based Intein Platform for Drug Production

The therapeutic and biochemical properties of proteins including antibodies can be enhanced by custom chemical functionalization that enables modifications, such as small molecule drug conjugation, PE...
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Eric Shusta, Cathryn Marshall | P150056US02

Technology

Small Molecule Catalysts of Oxidative Protein Folding

Approximately 20 percent of human proteins – including many of high pharmaceutical relevance – are believed to contain disulfide bonds critical for proper structure and function. However, producin...
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Ronald Raines, John Lukesh | P150010US02

Technology

Enhancing Cell Penetration to Improve Drug Delivery

The utility of many biologic drugs is limited by inefficient cellular delivery. There is a particular need for methods and reagents that facilitate delivery of peptides and proteins into the interior ...
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Ronald Raines, Kristen Andersen | P150031US02

Technology

Bovine Macrophage Cell Line

Macrophages are white blood cells that ingest foreign material and play a crucial role in the immune system. Presently, there is no bovine macrophage cell line available for research and testing purpo...
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Charles Czuprynski, Dhammika Atapattu, Josely Figueiredo | P140060US01

Technology

Adapted Rhinovirus C for Maximum Virus Yield

Human rhinoviruses (species A, B and C) encompass more than 160 types that are responsible for the majority of upper respiratory tract infections (common colds) and many of the lower respiratory tract...
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James Gern, Yury Bochkov, Ann Palmenberg, Kelly Watters | P160050US02

Technology

Streamlined Design for Transferring Analytes

Polymerase chain reaction (PCR) is used to generate copies of a particular DNA sequence. The technique is common and indispensable in many research applications. Unfortunately, methods for isolating/p...
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David Beebe, Ben Casavant, David Guckenberger, Scott Berry | P130361US01

Technology

Poly(UG) Polymerase: A Useful New RNA Tool

Enzymes called ribonucleotidyl transferases (NTases) add nucleotides to the ends of RNAs. At present only a few such enzymes are known, such as poly(A) polymerases and poly(U) polymerases. The selecti...
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Marvin Wickens, Melanie Preston | P140268US02

Technology

Circulating Tumor Cell Assay Using Simple Blood Draw

Circulating tumor cells (CTCs) are cells shed from tumor deposits that flow into the bloodstream. They are detected at a frequency of about one CTC per one billion surrounding blood cells. The great h...
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David Beebe, Joshua Lang, Ben Casavant, Scott Berry, Lindsay Strotman | P130171US01

Technology

Nanopore Antennas for Ultrahigh Speed DNA Sequencing

‘Nanopore sequencing’ allows a single molecule such as DNA to be analyzed without conventional tools like chemical labels or costly optical instruments. In the process, DNA strands and a stream of...
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Robert Blick, Abhishek Bhat, Paul Gwozdz | P140109US01

Technology

New Mass Spectrometry Detector Uses Optically Active Membrane

Mass spectrometers are analytical instruments that can precisely measure the mass of molecules to determine their composition and identity. Generally, the molecules are ionized and then accelerated by...
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Robert Blick, Jonathan Rodriguez, Hyunseok Kim, Zlatan Aksamija, Wolfgang Hansen, Christian Heyn | P140174US01

Technology

Synthesis of High-Density Oligomer Microarrays

To save time and costs, many alternatives to conventional DNA sequencing have been proposed. One approach utilizes an array of oligonucleotide probes (short nucleic acid chains) synthesized by photoli...
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Franco Cerrina, Viktoriya Golovkina | P05183US

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