Search Results
325 Results for 'Research Tools'
PAGE 6 OF 13
Technology
Bioluminescent Influenza Virions for High Throughput Screening
Assays currently used to detect neutralizing antibodies to influenza virus or measure virion binding to cells, antibodies or receptors require multiple steps. These steps are destructive, low sensitiv...
Learn More
Learn More
Andrew Mehle | P160304US01
Technology
Yeast-Based Intein Platform for Drug Production
The therapeutic and biochemical properties of proteins including antibodies can be enhanced by custom chemical functionalization that enables modifications, such as small molecule drug conjugation, PE...
Learn More
Learn More
Eric Shusta, Cathryn Marshall | P150056US02
Technology
Small Molecule Catalysts of Oxidative Protein Folding
Approximately 20 percent of human proteins – including many of high pharmaceutical relevance – are believed to contain disulfide bonds critical for proper structure and function. However, producin...
Learn More
Learn More
Ronald Raines, John Lukesh | P150010US02
Technology
Enhancing Cell Penetration to Improve Drug Delivery
The utility of many biologic drugs is limited by inefficient cellular delivery. There is a particular need for methods and reagents that facilitate delivery of peptides and proteins into the interior ...
Learn More
Learn More
Ronald Raines, Kristen Andersen | P150031US02
Technology
New Influenza B Virus Enables Real-Time Tracking of Disease Progression
Influenza infections in humans, from the common seasonal flu to the deadly pandemics of the 20th century, are caused chiefly by influenza A and influenza B viruses. Understanding the in vivo dynamics ...
Learn More
Learn More
Andrew Mehle | P160032US01
Technology
Enhanced Endotoxin Detection: New Advantages in Liquid Crystal Assays for Gram-Negative Pathogens
Gram-negative bacterial infections are an ongoing challenge to health care providers worldwide. Detection, treatment and control of such pathogens have gained increasing importance in the context of a...
Learn More
Learn More
Nicholas Abbott, Abhijit Dan | P160072WO01
Technology
Bovine Macrophage Cell Line
Macrophages are white blood cells that ingest foreign material and play a crucial role in the immune system. Presently, there is no bovine macrophage cell line available for research and testing purpo...
Learn More
Learn More
Charles Czuprynski, Dhammika Atapattu, Josely Figueiredo | P140060US01
Technology
Multiphoton Flow Cytometer for High Throughput Analysis of Multicellular Aggregates Like Pancreatic Islets
Regenerative medicine requires a practical, high throughput method of assessing the cellular components of multicellular entities before transplantation. Such a method would have many clinical and res...
Learn More
Learn More
Brenda Ogle, Luis Fernandez, Kevin Eliceiri, Matthew Hanson | P07386US
Technology
New Viral Propagation Method Yields Insight Into Childhood Asthma
In addition to the common cold, human rhinoviruses (RV) trigger nearly half of all cases of asthma exacerbation. Wheezing illnesses in infancy caused by RV are associated with a high risk of developin...
Learn More
Learn More
James Gern, Yury Bochkov, Ann Palmenberg | P140382US02
Technology
Adapted Rhinovirus C for Maximum Virus Yield
Human rhinoviruses (species A, B and C) encompass more than 160 types that are responsible for the majority of upper respiratory tract infections (common colds) and many of the lower respiratory tract...
Learn More
Learn More
James Gern, Yury Bochkov, Ann Palmenberg, Kelly Watters | P160050US02
Technology
Rat Model of Schizophrenia for Research and Preclinical Study
Schizophrenia is a complex neuropsychiatric disease afflicting up to 1 percent of the worldwide population. It affects perception, behavior and thinking and can have devastating social ramifications. ...
Learn More
Learn More
John-Paul Yu, Clifford Rubinstein | P160418US01
Technology
Monomeric Fluorescent Protein-Ligand Complexes with Strong Fluorescence in the Far-Red Region
Fluorescent proteins can be found today in most molecular biology laboratories. Since the discovery of Green Fluorescent Protein (GFP) in the early 1960s, fluorescent molecules have revolutionized man...
Learn More
Learn More
Wayne Schaefer, Ramaswamy Subramanian, Swagatha Ghosh | T150029WO01
Technology
Streamlined Design for Transferring Analytes
Polymerase chain reaction (PCR) is used to generate copies of a particular DNA sequence. The technique is common and indispensable in many research applications. Unfortunately, methods for isolating/p...
Learn More
Learn More
David Beebe, Ben Casavant, David Guckenberger, Scott Berry | P130361US01
Technology
Bio-Based Production of Non-Straight-Chain and Oxygenated Fatty Acids for Fuels and More
Fatty acids generally can be classified as straight-chain or non-straight-chain. Non-straight-chain fatty acids are less abundant and highly valued in dietary supplements, cosmetics, pharmaceuticals, ...
Learn More
Learn More
Timothy Donohue, Rachelle Lemke, Joshua Coon, Amelia Peterson, Michael Westphall | P140318US02
Technology
Modified E. coli for Enhanced Production of Pyruvate, Ethanol
Pyruvate is a starting material for synthesizing a variety of biofuels and chemicals. It can be readily converted into more than 60 commercial chemicals, including ethanol and several active pharmaceu...
Learn More
Learn More
Jennifer Reed, Xiaolin Zhang | P140301US02
Technology
High-Throughput Genome Editing and Engineering of Industrial Yeast, Other Fungi
As the industrial uses of yeast and other fungi expand, new systems are needed to genetically optimize strains for their intended use. In particular, the ability to manipulate prototrophic and diploid...
Learn More
Learn More
Christopher Hittinger, William Alexander | P140240US03
Technology
Poly(UG) Polymerase: A Useful New RNA Tool
Enzymes called ribonucleotidyl transferases (NTases) add nucleotides to the ends of RNAs. At present only a few such enzymes are known, such as poly(A) polymerases and poly(U) polymerases. The selecti...
Learn More
Learn More
Marvin Wickens, Melanie Preston | P140268US02
Technology
Circulating Tumor Cell Assay Using Simple Blood Draw
Circulating tumor cells (CTCs) are cells shed from tumor deposits that flow into the bloodstream. They are detected at a frequency of about one CTC per one billion surrounding blood cells. The great h...
Learn More
Learn More
David Beebe, Joshua Lang, Ben Casavant, Scott Berry, Lindsay Strotman | P130171US01
Technology
Accurate Determination of Metabolite Concentrations in Cell Extracts or Biological Fluids
Metabolomics, or the systematic study of all metabolites in an organism, is one of the fastest growing areas of scientific research. Nuclear magnetic resonance (NMR) spectroscopy is one tool used to a...
Learn More
Learn More
John Markley, Ian Lewis, William Westler, Qiu Cui, Gabriel Cornilescu, Marco Tonelli | P07362US
Technology
Nanopore Antennas for Ultrahigh Speed DNA Sequencing
‘Nanopore sequencing’ allows a single molecule such as DNA to be analyzed without conventional tools like chemical labels or costly optical instruments. In the process, DNA strands and a stream of...
Learn More
Learn More
Robert Blick, Abhishek Bhat, Paul Gwozdz | P140109US01
Technology
New Mass Spectrometry Detector Uses Optically Active Membrane
Mass spectrometers are analytical instruments that can precisely measure the mass of molecules to determine their composition and identity. Generally, the molecules are ionized and then accelerated by...
Learn More
Learn More
Robert Blick, Jonathan Rodriguez, Hyunseok Kim, Zlatan Aksamija, Wolfgang Hansen, Christian Heyn | P140174US01
Technology
Multiplexed Mass Spectrometry Quantification with Neutron-Encoded Mass Tags
In the past decade, cataloguing the thousands of proteins present in a cell using mass spectrometry (MS) has matured into a procedure both deeply vital and straightforward. Yet discovering how such mo...
Learn More
Learn More
Joshua Coon, Alexander Hebert | P130032US01
Technology
Reprogrammed Stem Cell Line for Research: IISH4i-CBT4
Reprogramming blood cells to induced pluripotent stem cells (iPSCs) provides a novel tool for studying hematopoietic development in vitro.
Learn More
Learn More
Igor Slukvin, Kejin Hu, James Thomson | P120130US02
Technology
Reprogrammed Stem Cell Line for Research: IISH3i-CB6
Reprogramming blood cells to induced pluripotent stem cells (iPSCs) provides a novel tool for studying blood development in vitro.
Learn More
Learn More
Igor Slukvin, Kejin Hu, James Thomson | P120130US01
Technology
Synthesis of High-Density Oligomer Microarrays
To save time and costs, many alternatives to conventional DNA sequencing have been proposed. One approach utilizes an array of oligonucleotide probes (short nucleic acid chains) synthesized by photoli...
Learn More
Learn More
Franco Cerrina, Viktoriya Golovkina | P05183US