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325 Results for 'Research Tools'
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Technology
New Disulfide-Bond Reducing Agent
Disulfide bonds between cysteine residues are the most common crosslinking agents in proteins. Reducing these bonds is an ordinary procedure in biochemistry and biotechnology. The most commonly used r...
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Ronald Raines, John Lukesh | P140284US01
Technology
Predicting Protein Hot Spot Residues
Most biological processes involve multiple proteins interacting with each other. While the principles governing protein-protein interactions are not fully understood, it is known that a small subset o...
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Julie Mitchell, Xiaolei Zhu, Steven Darnell | P140357US01
Technology
New Protein Production Strategy for Plants
In animals, plants and other eukaryotic organisms, typically one protein is translated from each mRNA. Usually, translation can start only at one end of the mRNA strand. In contrast, several viruses ...
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Aurelie Rakotondrafara, Jincan Zhang | P140069US02
Technology
Improved Ref Nuclease for Site-Specific DNA Cleavage
Restriction enzymes are commonly used to cleave double-stranded DNA. These enzymes bind to specific sequences of DNA (the ‘restriction site’) and cleave the DNA either at the recognition site or a...
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Michael Cox, Angela Gruber, Tayla Olsen | P130114US02
Technology
Controlling the Formation of Stem Cell Colonies with Tailored SAM Array
The substrate on which cells are cultured is key to successful growth and tissue generation. For example, it has been shown that attachment to a substrate by human embryonic stem cells influences whet...
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William Murphy, Angela Xie | P150062US01
Technology
Hydrogel Arrays for Screening Cell-Substrate Interactions, Now in Multiwell Format
While extensive research has been devoted to understanding the influence of medium conditions on cell development, researchers have only recently begun to understand the role of culture surface proper...
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William Murphy, Ngoc Nhi T. Le | P140305US01
Technology
Invertebrate Models for Studying Traumatic Brain Injury
Every year about two million cases of traumatic brain injury (TBI) occur in the United States, caused by falls, car crashes, sports collisions and other injuries. TBI can lead to a host of health prob...
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David Wassarman, Barry Ganetzky | P130267US02
Technology
New System for Producing Fungal Secondary Metabolites
Fungi produce a variety of chemical compounds called secondary metabolites that possess useful pharmaceutical properties. These compounds are invaluable platforms for developing front-line drugs. They...
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Nancy Keller, Philipp Wiemann | P150029US02
Technology
Hydrogel Arrays for Screening Cell-Substrate Interactions
While extensive research has been devoted to understanding the influence of medium conditions on cell development, researchers have only recently begun to understand the role of culture surface proper...
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William Murphy, Stefan Zorn, Ngoc Nhi T. Le, Michael Schwartz, Eric Nguyen | P140097US01
Technology
Protecting Groups for Boronic Acids
Boronic acids (i.e., compounds that have a single boron-carbon bond) are one of the most useful functional groups in organic chemistry and chemical biology. They have applications in polymer sciences,...
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Ronald Raines, Brett VanVeller, Matthew Aronoff | P130142US02
Technology
Wisconsin Miniature SwineTM for Biomedical Research
Rodents and other small animals are extensively used as models to study human health and disease, but there are increasing concerns about their relevance. Research funding and regulatory agencies are ...
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Jess Reed, Christian Krueger, Dhanansayan Shanmuganayagam, Thomas Crenshaw, Jamie Reichert, Joan Parrish | P130271US01
Technology
Wisconsin Miniature SwineTM for Cardiovascular Research
Rodents and other small animals are extensively used as models to study human health and disease, but there are increasing concerns about their relevance. Research funding and regulatory agencies are ...
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Jess Reed, Christian Krueger, Dhanansayan Shanmuganayagam, Thomas Crenshaw, Jamie Reichert, Joan Parrish | P140228US01
Technology
Mouse Model for Mania
Presently, there are no good rodent models for mania, which is a critical component of bipolar disorder. The most commonly used approach is to inject normal mice with amphetamines to produce hyperacti...
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Stephen Gammie | P100188US01
Technology
Computer-Based Determination of Haplotype
Humans are diploid organisms whose (non-sex) cells contain two copies of each chromosome – one from each parent. Each of these two copies may be distinguished by genetic variations such as insertion...
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Tom Anantharaman, Bud Mishra, Will Casey | P05170US
Technology
New Amphiphiles for Manipulating Membrane Proteins
Membrane proteins perform many crucial functions in vivo but are difficult to manipulate and study because they are not soluble in simple aqueous buffers. Solubilizing membrane proteins for physical c...
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Samuel Gellman, Pil Seok Chae | P09028US02
Technology
Use of Nanomaterials to Enrich Phosphopeptides for Mass Spectrometry-Based Proteomics
Proteomics is a relatively new discipline that is a large scale study of proteins. It includes systematically identifying the sequence, characterizing the structure and evaluating the function of all ...
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Song Jin, Ying Ge, Cory Nelson, Qingge Xu | P08123US02
Technology
Real-Time Tandem Mass Spectral Data Analysis for Protein Sequence Identification
Protein characterization has become an integral part of modern biology, even inspiring a new discipline known as proteomics, or the classification of proteins based on the genome of an organism. MS ...
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Joshua Coon, Gheorghe Craciun, Shane Hubler | P08040US
Technology
Polyclonal Antibodies Against Cardiovirus 2A, 2B, 2C, 3C, 3A, 3B and 3AB Proteins
Encephalomyocarditis virus, a cardiovirus, causes encephalitis and myocarditis. It is a widespread problem in swine, causing sudden death and reproductive failure and potentially leading to severe eco...
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Ann Palmenberg, Svetlana Amineva, Aleksey Aminev | P07499US
Technology
Polyclonal Antibodies Against Equine Rhinitis A Virus 3AB, 3C and 3D Proteins
Equine rhinitis A virus, formerly known as equine rhinovirus 1, causes a respiratory disease in horses similar to the common cold in humans. No vaccines against this virus are available commercially a...
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Ann Palmenberg, Svetlana Amineva, Aleksey Aminev | P07500US
Technology
Influenza Reporter Virus Imaged In Vivo
Currently, it is not possible to visualize the in vivo dynamics of an influenza infection. All existing models rely on proxies to measure viral replication (e.g., viral concentration in nasal washes) ...
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Andrew Mehle | P130288US01
Technology
Phosphine Ligands Made Cheaper, Better
Enantiomers are pairs of compounds that have the same chemical formula but different spatial structures (like your left and right hand, they are non-superimposable mirror images of each other). This i...
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Jennifer Schomaker, Robert Grigg, Ryan Van Hoveln | P130268US02
Technology
Identifying Related Peak Sets to Boost Mass Spectrometry Throughput
Tandem mass spectrometry (MS/MS) is a technique capable of identifying large numbers of proteins in complex biological samples. In the process, peptides are ionized and an initial survey scan (i.e., a...
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Joshua Coon, Michael Westphall, Derek Bailey | P120336US01
Technology
Designing Ubiquitin Oligomers
Ubiquitin (Ub) is a small protein composed of 76 amino acids and found throughout the cells of eukaryotic organisms. It folds into a compact globular structure, often as part of a complex of proteins....
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Eric Strieter, Ellen Valkevich, Robert Guenette | P120240US02
Technology
Increasing Secondary Metabolite Production in Fungus for Drug Development
Fungi produce a variety of chemical compounds called secondary metabolites. These compounds display a broad range of activities, including fighting off other fungi and bacteria. They also are useful f...
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Nancy Keller, Jin Woo Bok | P130203US01
Technology
Improved Disulfide-Bond Reducing Agents
Disulfide bonds between cysteine residues are the most common crosslinking agents in proteins. Reducing these bonds is an ordinary procedure in biochemistry and biotechnology. The most commonly used r...
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Ronald Raines, John Lukesh | P110330US02