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270 Results for 'Therapeutics & Vaccines'
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Technology
Anthelmintic Benzodiazepines with Reduced Sedative Activity
Schistosomiasis is an often-neglected tropical disease caused by blood flukes (helminths). The World Health Organization estimates that over 250 million people require preventive treatment for schisto...
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John Chan, James Cook, Md Yeunus Mian, Dishary Sharmin | T220009WO01
Technology
MICROBIAL COMMUNITIES THAT INHIBIT CLOSTRIDIOIDES DIFFICILE AND METHODS OF USING SAME
UW-Madison researchers have developed a workflow for identifying microbial strains that are effective in treating CDI. Using this workflow, they found that the ability for a microbiome (existing or tr...
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Ophelia Venturelli, Jordy Sulaiman | P240102US02
Technology
Synthesis of Novel Small Molecule CARM1 Degraders, Compounds Formed Thereby, and Pharmaceutical Compositions Containing Them
UW-Madison researchers have developed a focused library of CARM1 protein degraders. These degraders used a known binding molecule of CARM1 with an optimized linker attached to a Von Hippel–Lindau (V...
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Weiping Tang, Wei Xu, Haibo Xie, Megan Bacabac | P230336US02
Technology
Dietary Tripropionin Supplementation to Reduce Adiposity and Improve Glucose Homeostasis
UW-Madsion researchers have developed a method for reducing adiposity and promoting glucose homeostasis through consumption of tripropionin, a triglyceride containing three propionate fatty acids tail...
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Federico Rey, Evan Hutchison, Chi-Liang Yen | P240044US02
Technology
Treatment of Cancers With A Regimen of Targeted Radionuclide Therapy and Dual CAR T Cell Therapy
UW-Madison researchers have developed a new CAR T cell technology to be used in combination with targeted radionuclide treatment for treating sold tumors. The patient is dosed with low dose targeted r...
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Zachary Morris, Christian Capitini, Quaovi Sodji | P230294US02
Technology
Inhibitors of Naegleria Fowleri
UW-Madison researchers in collaboration with a researcher at Clemson University have developed a chemical scaffold that potently inhibits whole Naegleria fowleri parasites in culture. They have prepar...
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Jennifer Golden, Matthew Lish, James Morris | P240071US02
Technology
Hemoglobin-Based Nanoparticles
UW-Madison researchers have developed a multi-functional antibiotic nanoparticle that incorporates hemoglobin and the clinically approved antifungal agent naftifine in the core which is coated with re...
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Shaoqin Gong, Jingcheng Zhu | P230338US02
Technology
Single-Domain Antibodies And Variants Thereof Against Met
UW-Madison researchers have developed a novel camelid antibody against the cancer target cMET. As cMET is overexpressed on many tumors, this antibody may be useful for imaging tumors and/or delivering...
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Andrew Baschnagel, Randall Kimple, Reinier Hernandez, Aaron LeBeau | P230175US02
Technology
GENERATION OF PURE RETINAL CELLS FROM HUMAN PLURIPOTENT STEM CELLS
UW-Madison researchers have developed a novel protocol for generating nearly pure retinal progenitors (PAX6/VSX2 positive cells) without contamination by forebrain cells. Retinas develops from precurs...
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Su-Chun Zhang, Yunlong Tao | P230381US02
Technology
Ultra Low Dosage Zoledronic Acid For Treatment Of Retinal Disease
UW-Madison and UC-San Francisco researchers have developed a treatment for macular degeneration that uses low doses of the clinically approved molecule, zoledronic acid, which is used to treat bone di...
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Aparna Lakkaraju, Li Xuan Tan, Colin Germer | P230197US03
Technology
MICROBIAL COMMUNITIES THAT PRODUCE BUTYRATE FROM FIBER AND METHODS OF USING SAME TO PRODUCE BUTYRATE
UW-Madison researchers have developed a method for increasing butyrate production in the gut. The method includes delivering a microbial community that include certain bacteria, yeasts, and other micr...
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Ophelia Venturelli, Erin Ostrem, Ryan Clark | P230206US02
Technology
SELECTION SYSTEMS, PEPTIDES DETERMINED THEREWITH, AND METHODS OF USING SAME
UW-Madison inventors have developed a new PACE-based platform for rapid discovery of bioactive cyclic peptide protein aggregation inhibitors. By linking cyclic peptide activity to phage reproduction, ...
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Tina Wang, Linwei Yang | P230455US02
Technology
Antimony Chelates For Targeted Auger Therapy And Imaging Diagnostics
UW-Madison researchers in collaboration with researchers at the Oak Ridge National Laboratory have developed chelated antimony (Sb) that can be used for targeted Auger radiotherapy. While 119Sb has be...
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Jonathan Engle, Aeli Olson, Nikki Thiele, Briana Schrage, Md Faizul Islam | P230454US02
Technology
Cyclic Peptide-Based Lysosome Targeting Degraders
UW-Madison researchers have developed a protein degrader that shuttles targeted extracellular protein into the lysosome using a cyclic peptide that binds to a cellular receptor attached to a binding m...
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Weiping Tang, Yaxian Zhou, Yuan Zhao | P220339WO01
Technology
EXTRACELLULAR VESICLE THERAPY TO TREAT ORTHOPEDIC INJURY
UW-Madison researchers have developed methods for using mesenchymal stromal cell (MSC)-derived exosomes to promote ligament and tendon healing, including improvements to the mechanical properties of t...
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Peiman Hematti, Connie Chamberlain, John Kink, Ray Vanderby, Brian Walczak | P230034US02
Technology
Method To Make Small-Molecule Murine Double Minute 2 Protein (MDM2)-Degrading Compounds, Compounds Formed Thereby, And Pharmaceutical Compositions Containing Them
The development of small-molecule compounds that target the murine double minute 2 protein (MDM2) represents a significant advancement in cancer therapy. MDM2 is known to inhibit the tumor suppressor ...
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Weiping Tang, Bo Wang, Suzhen Wu, Ka Yang | P190076US02
Technology
Lipid-Peptide Fusion Inhibitors As SARS-CoV-2 Antivirals
UW Madison researchers and collaborators present a method of treating COVID-19 with lipid- peptide fusion antiviral therapy. Also described is a composition and method of treating Ebola with lipid-pep...
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Samuel Gellman, Anne Moscona, Matteo Porotto, Victor Outlaw, Zhen Yu | P200290US02
Technology
Kir 7.1 Gene Therapy Vectors And Methods Of Using The Same
The present invention from UW Madison researchers is directed to improved AAV gene therapy constructs and pharmaceutical compositions for the expression of Kir7.1. The gene therapy constructs are part...
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Bikash Pattnaik, Pawan Shahi | P180340US05
Technology
Inhibitors Of Encephalitic Alphaviruses
The present invention from UW Madison inventors and collaborators is a set of two distinct small molecule scaffolds that have been developed as antiviral agents against Venezuelan Equine Encephalitic ...
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Jennifer Golden, Xufeng Cao, Donghoon Chung, Colleen Jonsson, Michael Ryan, Xiaoyu Li, Jongwoo Son | P170217US02
Technology
Biomimetic, Reactive Oxygen Species-Detonable Nanoclusters For Antirestenotic Therapy
UW-Madison researchers along with collaborators engineered a multimodal nanocluster drug delivery particle for treating restenosis. The researchers formed the nanocluster by self-assembly of H40-polyl...
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Shaoqin Gong, Yi Zhao, Kenneth Kent, Lianwang Guo, Bowen Wang, Takuro Shirasu | P210367US02
Technology
Activating Appendages To Induce Polypharmacology In Peptide Hormone Analogues, Including Dual GLP-1R / GIP Agonism
UW-Madison researchers have developed a synthetic peptide through a single amino acid substitution and chemical conjugation of an aromatic molecule at the site of mutation that turns a peptide that bi...
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Samuel Gellman, Kyle Brown, Rylie Morris | P230413US02
Technology
Siderophore-Polymer Conjugates For Increasing Bacterial Sensitivity To Antibiotics
The present technology from UW-Madison researchers provides siderophore-polymer conjugates that enhance the sensitivity of bacteria to antibiotics, e.g., Pseudomonas, P. aeruginosa, Acinetobacter, and...
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May Xiong, Max Purro | P160355US03
Technology
Microorganisms And Methods For Producing Reuterin
UW-Madison researchers have developed a method to optimize the production of reuterin in bacterial cells that contain the reuterin production pathway (i.e., the pdu operon). The inventors compared the...
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Jan Peter Van Pijkeren, Zhiying Wang | P230254US02
Technology
Turbinmicin Compounds, Compositions And Uses Thereof
The present invention from UW-Madison researchers is a small molecule antifungal agent isolated from a bacterial species found in the sea squirt Ecteinascidia turbinate. The inventors collected the sp...
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Timothy Bugni, Fan Zhang, Douglas Braun, David Andes, Miao Zhao | P180376US02
Technology
METHOD FOR PREVENTING ADVERSE PREGNANCY OUTCOMES DUE TO USE OF SELECTIVE SEROTONIN REUPTAKE INHIBITORS (SSRI) DURING GESTATION
UW-Madison researchers have discovered methods for alleviating the adverse effects of SSRIs in pregnancy through the co-administration of the known drug ketanserin. Using several in vivo experimental ...
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Laura Hernandez, Rafael Reis Domingues, Milo Wiltbank | P230203US02