A UW-Madison researcher has engineered Lactobacillus reuteri (L. reuteri VPL1014) to express a recombinant gene from the chromosome or plasmid. The gene product can be rodent-, monkey-, or human-deriv...
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A UW-Madison researcher has engineered Lactobacillus reuteri (L. Reuteri VPL1014) to encode a native antirepressor protein whose expression is placed under the control of an inducible promoter along w...
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UW-Madison researchers have developed a formulation of biologically active immunostimulatory proteins that are delivered specifically into the tumor microenvironment. The researchers use a non-pathoge...
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UW-Madison researchers have developed an improved and simpler method for rapidly attaching azide (N3) groups to proteins in solution. Whereas the reaction described in P220072 required an oxidative re...
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UW-Madison researchers have developed two methods and related materials for promoting binding of mRNA LNPs to minerals. In the first, a positively charged lipid (e.g., DOTAP) is substituted/incorporat...
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The UW inventors and collaborators developed a new modality of directly “painting” drug-loaded unimolecular micelles (UM) to the adventitia thus obviating the need for a hydrogel. To render tissue...
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This invention from UW Madison researchers presents recombinant microorganisms and methods of using same. The recombinant microorganisms include one or more modifications that reduce the expression an...
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The present invention from UW Madison researchers is directed to improved AAV gene therapy constructs and pharmaceutical compositions for the expression of Kir7.1. The gene therapy constructs are part...
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UW-Madison researchers along with collaborators engineered a multimodal nanocluster drug delivery particle for treating restenosis. The researchers formed the nanocluster by self-assembly of H40-polyl...
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UW-Madison researchers have discovered rearrangement sequences that can be used to engineer rAAV vectors so that they may assemble larger therapeutic transgenes. Using forward and reverse primers that...
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UW-Madison researchers have developed a new combination adjuvant composition (dubbed QTAP) that combines two safe adjuvants (Quil-A and DOTAP) using a nanoparticle preparation protocol developed by th...
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UW-Madison researchers have identified new antibodies and related single-chain antibody fragments (scFvs) that bind and transport across the brain vasculature. These promising antibodies were discover...
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UW researchers have developed a polymeric nanoparticle to package and deliver a CRISPR/Cas protein/guide RNA complex and, optionally, a single stranded DNA repair template into cells for gene therapy....
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UW-Madison researchers have developed a novel lipid nanoparticle for delivering biomolecules. The researchers designed the lipopeptide-based nanoparticle for efficient delivery of various biomolecules...
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UW-Madison researchers have developed a novel platform that can selectively and sustainably scavenge ROS in inflamed colon tissues while also improving probiotic delivery for gut microbiota homeostasi...
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UW-Madison researchers have developed a novel, cross-species antibody to fibroblast activation protein (FAP). The researchers identified the antibody through screening of a phage display library. That...
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UW-Madison researchers have developed a novel approach for enhancing pyroptosis, which could prove beneficial in treating cancer. The inventors combine intracellular delivery of gasdermin with a small...
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UW-Madison researchers have developed approaches to improve recombinant AAV gene therapy vectors (rAAV) therapies by improving their expression in target cells. The inventors have discovered that the ...
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UW-Madison researchers have discovered a regulatory system that controls the activation of certain prophages in the genome of Lactobacillus reuteri, which result in the bursting of the L. reuteri cell...
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UW-Madison researchers have developed antibodies or antigen binding fragments thereof (i.e., single chain variable fragment (scFv)) that specifically bind to the blood brain barrier (BBB). The researc...
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UW-Madison researchers have developed a dendron-micelle (DM) nanoparticle platform that can be used for combination therapy in the treatment of interstitial lung disease (ILD), including idiopathic pu...
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UW-Madison researchers have identified new antibodies and related single-chain antibody fragments (scFvs) that bind and transport across the brain vasculature. These promising antibodies were discover...
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UW researchers have developed a polymeric nanoparticle to package and deliver a CRISPR/Cas protein/guide RNA complex and, optionally, a single stranded DNA repair template into cells for gene therapy....
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Two UW-Madison researchers have developed a sequential coating strategy to improve the efficacy of probiotics used in the treatment of IBD.  The probiotic is first coated with a tannic acid (TA) laye...
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UW-Madison researchers successfully developed and demonstrated improved mRNA stabilization techniques that leverage mineral coatings. In short, the inventors stabilized mRNA complexes on mineral coate...
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