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With an increasing interest in using the CRISPR/Cas9 system for gene editing, there comes a strong need to develop tools for delivering the CRISPR machinery safely and efficiently into cells. Existing...
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With the explosion of interest in using the CRISPR/Cas9 system for gene editing, there is a strong focus on developing tools for delivering the CRISPR machinery safely and efficiently into cells. Exis...
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Polypeptides, such as enzymes, antibodies, hormones and cytokines, are useful therapeutic agents. However, routes for systemically introducing such polypeptides to a subject are limited. Oral administ...
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New tools for human gene editing are rapidly advancing all sectors of biomedicine from basic biology to somatic gene therapy in the clinic. Precise editing of DNA sequences in the human genome can be ...
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Two-drug combinations of paclitaxel and rapamycin (an mTOR inhibitor) as well as paclitaxel and 17-AAG (an enhanced version of geldanamycin and Hsp90 inhibitor) have progressed into human clinical tri...
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Chemoselective transformations are of key importance in modern chemical biology. Protein esterification can, for example, be employed for labeling, enhanced cellular uptake and other useful protein mo...
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Drug delivery to the brain is hampered by the presence of the blood-brain barrier (BBB), which excludes more than 98 percent of small molecule pharmaceuticals and nearly 100 percent of all protein and...
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In addition to key roles in food and biofuel production, probiotic strains of lactic acid bacteria are being exploited in medicine as therapeutic delivery vehicles. One obstacle is that bacteriophages...
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The utility of many biologic drugs is limited by inefficient delivery into cells. Strategies to overcome this limitation have included enhancing the attraction between positively charged drug agents a...
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The utility of many biologic drugs is limited by inefficient cellular delivery. There is a particular need for methods and reagents that facilitate delivery of peptides and proteins into the interior ...
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Emulsions containing soybean oil have been used intravenously for more than 40 years. Recently they have been employed in the delivery of certain hydrophobic drugs such as anti-inflammatory agents and...
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Emulsions containing soybean oil have been used intravenously for more than 40 years. Recently they have been employed in the delivery of certain hydrophobic drugs such as anti-inflammatory agents and...
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Amyotrophic lateral sclerosis (ALS) is a devastating disease with no effective treatment. In patients with ALS, the neurons in their brains degenerate, leading to cognitive and physical breakdown. Oth...
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Even though therapeutic compounds have been developed for neurologic disorders such as Alzheimer’s disease, these conditions remain difficult to treat in large part because of the blood-brain barrie...
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Genome editing has proven difficult in cells, especially mammalian cells. One way to improve efficiency is to introduce a double-strand break (DSB) in the desired DNA region. These DSBs stimulate cell...
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Chronic myeloid leukemia (CML) is a disorder driven by overproliferating leukemia cells in bone marrow and blood. Targeted therapy uses thyrosine kinase inhibitors to inhibit leukemia cells, but fails...
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As cancer research progresses, it is evident that single drug formulations only provide limited success. Developing combination therapies would greatly benefit patients, especially those who must fol...
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The utility of many biologic drugs is limited by inefficient delivery into cells. Strategies to overcome this limitation have included enhancing the attraction between positively charged drug agents a...
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