With an increasing interest in using the CRISPR/Cas9 system for gene editing, there comes a strong need to develop tools for delivering the CRISPR machinery safely and efficiently into cells. Existing...
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With the explosion of interest in using the CRISPR/Cas9 system for gene editing, there is a strong focus on developing tools for delivering the CRISPR machinery safely and efficiently into cells. Exis...
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Polypeptides, such as enzymes, antibodies, hormones and cytokines, are useful therapeutic agents. However, routes for systemically introducing such polypeptides to a subject are limited. Oral administ...
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Slippery liquid-infused porous surfaces (SLIPS) are an emerging class of materials with unique antifouling properties and applications ranging from biomedical device coatings and consumer products to ...
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Two-drug combinations of paclitaxel and rapamycin (an mTOR inhibitor) as well as paclitaxel and 17-AAG (an enhanced version of geldanamycin and Hsp90 inhibitor) have progressed into human clinical tri...
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Chemoselective transformations are of key importance in modern chemical biology. Protein esterification can, for example, be employed for labeling, enhanced cellular uptake and other useful protein mo...
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Drug delivery to the brain is hampered by the presence of the blood-brain barrier (BBB), which excludes more than 98 percent of small molecule pharmaceuticals and nearly 100 percent of all protein and...
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In addition to key roles in food and biofuel production, probiotic strains of lactic acid bacteria are being exploited in medicine as therapeutic delivery vehicles. One obstacle is that bacteriophages...
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The utility of many biologic drugs is limited by inefficient delivery into cells. Strategies to overcome this limitation have included enhancing the attraction between positively charged drug agents a...
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The utility of many biologic drugs is limited by inefficient cellular delivery. There is a particular need for methods and reagents that facilitate delivery of peptides and proteins into the interior ...
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Cancer treatment planning remains an ongoing challenge to oncologists and patients alike, with each cancer being genetically unique and requiring personalized approaches. Greater outcome success will ...
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Emulsions containing soybean oil have been used intravenously for more than 40 years. Recently they have been employed in the delivery of certain hydrophobic drugs such as anti-inflammatory agents and...
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Emulsions containing soybean oil have been used intravenously for more than 40 years. Recently they have been employed in the delivery of certain hydrophobic drugs such as anti-inflammatory agents and...
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Even though therapeutic compounds have been developed for neurologic disorders such as Alzheimer’s disease, these conditions remain difficult to treat in large part because of the blood-brain barrie...
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As cancer research progresses, it is evident that single drug formulations only provide limited success. Developing combination therapies would greatly benefit patients, especially those who must fol...
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The utility of many biologic drugs is limited by inefficient delivery into cells. Strategies to overcome this limitation have included enhancing the attraction between positively charged drug agents a...
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The ability to control the delivery of biomolecules to cells and tissues has many therapeutic and research applications. In particular, spatial and temporal control over the release of multiple biolog...
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Many powerful drugs have only limited usefulness because they are relatively insoluble in aqueous solutions. For example, gossypol has been identified as an effective inhibitor of Bcl-2 proteins, whic...
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Oral ingestion of pharmaceuticals is considered the safest, most convenient and most economical method of administering drugs. However, many pharmaceuticals cannot be delivered orally because they are...
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The safe and efficient delivery of DNA into cells is essential for the clinical success of gene therapy. Synthetic polymers are considered long-term alternatives to virus-based gene delivery agents be...
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Methods that allow reactive polymer films to be deposited or assembled on topologically complex substrates are useful for the patterning or chemical modification of surfaces in a broad range of applic...
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The ability to deliver biomolecules, such as proteins or nucleic acids, into cells has many therapeutic and research applications. Polyelectrolyte multilayers (PEMs) have been used to deliver biomolec...
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The ability to deliver proteins into cells has many therapeutic and research applications. However, peptide drugs and therapeutic proteins are notoriously difficult to administer, in part because of t...
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Chitosan is a soluble biopolymer derived from chitin, which is a structural element in the shell of marine arthropods.  Chitosan is used in water processing and agriculture.  It also is used...
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Oral ingestion of pharmaceuticals currently is considered the safest, most convenient and most economical method of drug administration. However, oral delivery of many pharmaceuticals is not possible ...
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