UW-Madison researchers have identified new antibodies and related single-chain antibody fragments (scFvs) that bind and transport across the brain vasculature. These promising antibodies were discover...
Learn More

UW researchers have developed a polymeric nanoparticle to package and deliver a CRISPR/Cas protein/guide RNA complex and, optionally, a single stranded DNA repair template into cells for gene therapy....
Learn More

Two UW-Madison researchers have developed a sequential coating strategy to improve the efficacy of probiotics used in the treatment of IBD.  The probiotic is first coated with a tannic acid (TA) ...
Learn More

UW-Madison researchers successfully developed and demonstrated improved mRNA stabilization techniques that leverage mineral coatings. In short, the inventors stabilized mRNA complexes on mineral coate...
Learn More

UW-Madison researchers have developed a retinal organoid model system for evaluating therapies that target genetic mutations. The inventors have discovered that genetic modifications that compromise t...
Learn More

Described herein are methods, compositions, and kits for directed differentiation of human pluripotent stem cells, neuromesodermal progenitors, and neural stem cells into bioengineered elliptical neur...
Learn More

Methods for obtaining populations of norepinephrine (NE) neuronal progenitor cells and creating enriched populations of NE neurons are provided herein. Also provided herein are methods for obtaining g...
Learn More

UW-Madison researchers have developed a nanoparticle-based platform comprising targeting agents (i.e., tumor selective peptides) and active agents (e.g., immuno- and chemo-drugs).  The nanopartic...
Learn More

Provided herein are silica metal organic framework (SMOF) nanoparticles that are pH-responsive for delivery of bioactive molecules. The nanoparticles include a organosilica network comprising a plural...
Learn More

Differentiation of normal stem cells into the correct cell lineage is a tightly controlled process that involves cell-cell and cell-extracellular matrix interactions as well as signaling through cellu...
Learn More

The present technology provides a nanoparticle comprising: a silica network comprising crosslinked polysiloxanes, wherein the crosslinks between polysiloxanes comprise disulfide linkages, the polysilo...
Learn More

A method of differentiating embryonic stem cells into ventral spinal progenitor cells is disclosed. In one embodiment, the invention comprises culturing a population of cells comprising a majority of ...
Learn More

The invention provides biomarker profiles of cellular metabolites and methods for screening chemical compounds including pharmaceutical agents, lead and candidate drug compounds and other chemicals us...
Learn More

The present disclosure provides for methods of diagnosing and treating bacterial infections. Human Intelectin 1 (hIntL-1) has been shown to bind selectively to glycan components on bacteria including ...
Learn More

A method of enhancing therapeutic/drug transport to the perivascular space of the brain of a patient is disclosed. In one embodiment, the method comprises the step of introducing a therapeutic/drug an...
Learn More

The present disclosure provides for methods providing a pre/probiotic agent to a subject. Human Intelectin 1 (hIntL-1) has been shown to bind selectively to glycan components on bacteria, thereby prom...
Learn More

A unimolecular nanoparticle, a composition thereof, and methods of use thereof that includes 1) a dendritic polymer having a molecular weight of about 500-120,000 Da and terminating in hydroxyl, amino...
Learn More

Provided herein are peptides comprising an amino acid sequence having at least about 85% sequence identity to RYRPRAPIIAVT (SEQ ID NO: 1). These cationic peptides inhibit PKM2 methylation and may be u...
Learn More

Described herein are methods, compositions, and kits for directed differentiation of human pluripotent stem cells, neuromesodermal progenitors, and neural stem cells into biomimetic neural tissues com...
Learn More

The present invention discloses an ionic liquid composition comprising an at least partially hydrophobic ionic liquid, wherein the at least partially hydrophobic ionic liquid comprises a dication comp...
Learn More

The present invention relates to substantially planar vascularized brain cancer organoid and methods of using such vascularized brain cancer organoids in anti-cancer drug discovery screen. In particul...
Learn More

Disclosed are compositions and methods for the co-delivery of ribonucleic acids and interferon binding proteins. Compositions include mineral coated microparticles having a mineral layer, a ribonuclei...
Learn More

Disclosed are formulations for providing a therapeutic bioactive polypeptide to injured tissue. Formulations include mineral coated microparticles wherein a polynucleotide is adsorbed to the mineral l...
Learn More

The present invention provides therapeutic formulations, including therapeutic nanoemulsions, and related methods for the in vivo delivery of hydrophobic compounds. Formulations and methods of the inv...
Learn More

An expression cassette for gene silencing and replacement, including, in operable communication, a promoter, an expression attenuator, a nucleotide sequence encoding a gene for a replacement target pr...
Learn More