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55 Results for 'Drug Delivery'
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Technology
Vector For Gene Silencing And Replacement And Methods Of Use Thereof
Erik Dent, Matthew Millette | P180170US02
Technology
Stable Theranostic And Therapeutic Nanoemulsions Using Triphilic Semifluorinated Amphiphiles
Sandro Mecozzi, Alexa Barres | P170292US02
Technology
Mineral Coated Microparticles For Gene Delivery In Chronic Wound Therapy
William Murphy, Andrew Khalil, Xiaohua Yu | P170173US02
Technology
Mineral Coated Microparticles For Co-Delivery Of Anti-Inflammatory Molecules With Nucleic Acids To Improve Gene Delivery Outcomes
William Murphy, Andrew Khalil, Xiaohua Yu | P170170US02
Technology
Human Pluripotent Stem Cell-Derived Brain Organoids For Cancer Modeling And Drug Screening
William Murphy, Elizabeth Aisenbrey, Elizabeth Torr, Victoria Harms, Gaurav Kaushik | P190185US02
Technology
An Ionic Liquid-Based Nanoemulsion Formulation For The Efficient Delivery Of Hydrophobic Therapeutic Agents
Sandro Mecozzi, Moira Esson | P180283US02
Technology
Methods And Culture Substrates For Controlled Induction Of Biomimetic Neural Tissues Comprising Singular Rosette Structures
Randolph Ashton, Gavin Knight | P170180US02
Technology
Polyplex Delivery System For Proteins, Nucleic Acids And Protein/Nucleic Acid Complexes
With an increasing interest in using the CRISPR/Cas9 system for gene editing, there comes a strong need to develop tools for delivering the CRISPR machinery safely and efficiently into cells. Existing...
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Shaoqin Gong, Yuyuan Wang, Krishanu Saha, Amr Abdeen | P180158US02
Technology
Nanocapsule Delivery System For Ribonucleoproteins
With the explosion of interest in using the CRISPR/Cas9 system for gene editing, there is a strong focus on developing tools for delivering the CRISPR machinery safely and efficiently into cells. Exis...
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Shaoqin Gong, Krishanu Saha, Guojun Chen, Amr Abdeen, Yuyuan Wang, Ruosen Xie | P170376US02
Technology
Engineered Probiotics as Systemic Therapeutic Delivery Platform
Polypeptides, such as enzymes, antibodies, hormones and cytokines, are useful therapeutic agents. However, routes for systemically introducing such polypeptides to a subject are limited. Oral administ...
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Jan Peter Van Pijkeren, Alan Attie, Mark Keller, Jeehwan Oh | P160109US02
Technology
S1mplex: A New Tool for Precision Gene Editing
New tools for human gene editing are rapidly advancing all sectors of biomedicine from basic biology to somatic gene therapy in the clinic. Precise editing of DNA sequences in the human genome can be ...
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Krishanu Saha, Jared Carlson-Stevermer, Amr Abdeen, Lucille Kohlenberg | P170309US02
Technology
An Injectable Nanovehicle for a Cancer Treatment Combination of Paclitaxel, Rapamycin and 17-AAG
Two-drug combinations of paclitaxel and rapamycin (an mTOR inhibitor) as well as paclitaxel and 17-AAG (an enhanced version of geldanamycin and Hsp90 inhibitor) have progressed into human clinical tri...
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Glen Kwon | P090383US03
Technology
Reagents for Bioreversible Protein Esterification
Chemoselective transformations are of key importance in modern chemical biology. Protein esterification can, for example, be employed for labeling, enhanced cellular uptake and other useful protein mo...
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Ronald Raines, Kalie Mix | P150262US03
Technology
Enhanced Drug Delivery Across the Blood-Brain Barrier: pH-Dependent Antibodies Targeting the Transferrin Receptor
Drug delivery to the brain is hampered by the presence of the blood-brain barrier (BBB), which excludes more than 98 percent of small molecule pharmaceuticals and nearly 100 percent of all protein and...
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Eric Shusta, Benjamin Tillotson | P150370US02
Technology
Phage-Cured Lactobacillus Strains for Therapeutic Delivery
In addition to key roles in food and biofuel production, probiotic strains of lactic acid bacteria are being exploited in medicine as therapeutic delivery vehicles. One obstacle is that bacteriophages...
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Jan Peter Van Pijkeren, Jeehwan Oh | P170020US01
Technology
Bioreversible Boronates Improve Drug Delivery
The utility of many biologic drugs is limited by inefficient delivery into cells. Strategies to overcome this limitation have included enhancing the attraction between positively charged drug agents a...
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Ronald Raines, Thomas Smith | P150009US02
Technology
Enhancing Cell Penetration to Improve Drug Delivery
The utility of many biologic drugs is limited by inefficient cellular delivery. There is a particular need for methods and reagents that facilitate delivery of peptides and proteins into the interior ...
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Ronald Raines, Kristen Andersen | P150031US02
Technology
Lipid-Free Emulsions for Delivering Anesthesia, Other Hydrophobic Drugs
Emulsions containing soybean oil have been used intravenously for more than 40 years. Recently they have been employed in the delivery of certain hydrophobic drugs such as anti-inflammatory agents and...
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Sandro Mecozzi, Robert Pearce | P140235US02
Technology
Lipid-Free, Stabilized Emulsions for Delivering Anesthesia and Other Hydrophobic Drugs
Emulsions containing soybean oil have been used intravenously for more than 40 years. Recently they have been employed in the delivery of certain hydrophobic drugs such as anti-inflammatory agents and...
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Sandro Mecozzi, Robert Pearce, William Tucker | P140337US02
Technology
New Target for Diagnosing, Treating Neurodegenerative Diseases
Amyotrophic lateral sclerosis (ALS) is a devastating disease with no effective treatment. In patients with ALS, the neurons in their brains degenerate, leading to cognitive and physical breakdown. Oth...
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Su-Chun Zhang, Hong Chen | P140125US02
Technology
Blood-Brain Barrier Targeting Antibodies to Improve Drug Delivery
Even though therapeutic compounds have been developed for neurologic disorders such as Alzheimer’s disease, these conditions remain difficult to treat in large part because of the blood-brain barrie...
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Eric Shusta, Angela Jones, Charles Stutz | P140126US02
Technology
Gene Editing Tool Uses New Enzyme
Genome editing has proven difficult in cells, especially mammalian cells. One way to improve efficiency is to introduce a double-strand break (DSB) in the desired DNA region. These DSBs stimulate cell...
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James Thomson, Zhonggang Hou, Yan Zhang, Rakhi Rajan, Erik Sontheimer, Alfonso Mondragón | P130315US02
Technology
Treating Chronic Myeloid Leukemia
Chronic myeloid leukemia (CML) is a disorder driven by overproliferating leukemia cells in bone marrow and blood. Targeted therapy uses thyrosine kinase inhibitors to inhibit leukemia cells, but fails...
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Igor Slukvin, Kran Suknuntha | P130277US02
Technology
Thermogel for Combination Drug Delivery
As cancer research progresses, it is evident that single drug formulations only provide limited success. Developing combination therapies would greatly benefit patients, especially those who must fol...
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Glen Kwon, Hyunah Cho | P130338US03
Technology
Improving Drug Delivery with Boronic Acids
The utility of many biologic drugs is limited by inefficient delivery into cells. Strategies to overcome this limitation have included enhancing the attraction between positively charged drug agents a...
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Ronald Raines, Gregory Ellis, Michael Palte | P110315US02