Polyclonal Antibodies Against Cardiovirus 2A, 2B, 2C, 3C, 3A, 3B and 3AB Proteins
Inventors: Ann Palmenberg, Svetlana Amineva, Aleksey Aminev
The Wisconsin Alumni Research Foundation (WARF) is seeking commercial partners interested in polyclonal antibodies against several cardiovirus proteins.
Encephalomyocarditis virus, a cardiovirus, causes encephalitis and myocarditis. It is a widespread problem in swine, causing sudden death and reproductive failure and potentially leading to severe economic losses for pork producers. This virus also infects exotic mammals such as elephants and llamas.
UW-Madison researchers have developed polyclonal mouse antibodies against recombinant cardiovirus proteins. The antibodies can be used for specific molecular recognition of the cardiovirus proteins in vitro or in vivo using experimental techniques such as ELISA (enzyme linked immunosorbent assay), Western assays, protein immunoprecipitation (IP) and confocal fluorescence microscopy.
- Studying cardiovirus proteins
- May lead to new means of detecting, preventing and treating cardiovirus infection, including encephalomyocarditis virus infection
- All reagents have been tested for efficacy.
- Most of the antibodies react with viral precursor proteins, in addition to the mature proteins against which they were raised.
For More Information About the Inventors
- Aminev A.G., Amineva S.P. & Palmenberg A.C. 2003. Encephalomyocarditis Virus (EMCV) Proteins 2A and 3BCD Localize to Nuclei and Inhibit Cellular mRNA Transcription but not rRNA Transcription. Virus Res. 95, 59-73.
- Aminev A.G., Amineva S.P. & Palmenberg A.C. 2003. Encephalomyocarditis Viral Protein 2A Localizes to Nucleoli and Inhibits Cap-Dependent mRNA Translation. Virus Res. 95, 45-57.