Mouse Monoclonal Antibody Against the Alpha Subunit of E. coli RNA Polymerase
Inventors: Richard Burgess, Nancy Thompson
The Wisconsin Alumni Research Foundation (WARF) is seeking commercial partners interested in developing a mouse monoclonal antibody that specifically recognizes the alpha subunit of E. coli RNA polymerase.
RNA polymerase is the enzyme responsible for DNA transcription, the process of making an RNA copy of a DNA gene sequence. The core RNA polymerase enzyme in E. coli consists of two alpha subunits, a beta subunit and a beta` subunit. The alpha subunits are responsible for assembling the subunits into the enzyme.
UW-Madison researchers have developed a mouse monoclonal antibody, known as 4RA1, which specifically recognizes the alpha subunit of E. coli RNA polymerase.
- Western blot experiments