Wisconsin Alumni Research Foundation

Pluripotent Stem Cells
Pluripotent Stem Cells
Induction Of Arterial-Type Of Hemogenic Endothelium (Ahe) And Enhancement Of T Cell Production From Pscs Through Overexpression Of Ets Factors Or Modulating Mapk/Erk Signalling Pathways
WARF: P170133US02

Inventors: Igor Slukvin, Mi Ae Park, Akhilesh Kumar

The Invention
The present invention is a method of creating a population of hemogenic endothelial cells with arterial specification and enhanced T cell potential. In one embodiment, the method uses ETS transgene induction at the mesodermal stage of differentiation. In another embodiment, the method activates ERK and NOTCH signaling at the mesodermal stage of differentiation.
Additional Information
For More Information About the Inventors
For current licensing status, please contact Andy DeTienne at [javascript protected email address] or 608-960-9857