Drug Discovery & Development
Adhesion Molecule Inhibition for Stem Cell Therapies
WARF: P220064US02
Inventors: Matthew Brown
The Invention
A UW researcher has developed immune evading pluripotent stem cells by knocking down cell adhesion molecules in pluripotent stem cell lines. He differentiated those cells into cardiomyocytes or epithelial cells and observed that the target adhesion protein remained knocked down in the differentiated cells. He targeted the protein CD54 in initial experiments but plans to test p-selectin and e-selectin as targets for preventing immune cells recognizing differentiated pluripotent stem cells as foreign.
The next steps for the inventor are to test the ability of immune cells to attach to the CD54- cells. He also plans to do animal testing using the humanized mice the core creates.
Additional Information
For More Information About the Inventors
Tech Fields
For current licensing status, please contact Jennifer Gottwald at [javascript protected email address] or 608-960-9854