Wisconsin Alumni Research Foundation

Technology

A UW-Madison researcher has developed an oral combination therapy for treating fibrolamellar carcinoma (FLC) that utilizes a CDK7 inhibitor and a CDK9 inhibitor. The researcher created a cancer cell l...
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Sean Ronnekleiv-Kelly | P240225US02

Technology

Single-Domain Antibodies and Variants Thereof Against Opioids

UW-Madison researchers and collaborators have developed a suite of four camelid antibodies that specifically bind to fentanyl and carfentanil, a major metabolite of fentanyl. One binds specifically to...
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Aaron LeBeau, Joseph Gallant, Marco Pravetoni, Carly Baehr, Hideki Aihara, Dustin Hicks | P230209US02

Technology

Virus-Free CRISPR Car Natural Killer Cells

UW-Madison researchers have developed a non-viral method of developing CAR NK cells. The inventors tested many parameters along established processes for genetically modifying immune cells without vir...
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Krishanu Saha, Keerthana Shankar | P240105US02

Technology

Inhibitors of Naegleria Fowleri

UW-Madison researchers in collaboration with a researcher at Clemson University have developed a chemical scaffold that potently inhibits whole Naegleria fowleri parasites in culture. They have prepar...
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Jennifer Golden, Matthew Lish, James Morris | P240071US02

Technology

Hemoglobin-Based Nanoparticles

UW-Madison researchers have developed a multi-functional antibiotic nanoparticle that incorporates hemoglobin and the clinically approved antifungal agent naftifine in the core which is coated with re...
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Shaoqin Gong, Jingcheng Zhu | P230338US02

Technology

Single-Domain Antibodies And Variants Thereof Against Met

UW-Madison researchers have developed a novel camelid antibody against the cancer target cMET. As cMET is overexpressed on many tumors, this antibody may be useful for imaging tumors and/or delivering...
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Andrew Baschnagel, Randall Kimple, Reinier Hernandez, Aaron LeBeau | P230175US02

Technology

Cyclic Peptide-Based Lysosome Targeting Degraders

UW-Madison researchers have developed a protein degrader that shuttles targeted extracellular protein into the lysosome using a cyclic peptide that binds to a cellular receptor attached to a binding m...
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Weiping Tang, Yaxian Zhou, Yuan Zhao | P220339WO01

WARF