Hyperlipidemia is a condition strongly associated with obesity and is an independent risk factor for the development of coronary heart disease. To help combat hyperlipidemia, the pharmaceutical indust...
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Multiple sclerosis (MS) is a chronic autoimmune disease that afflicts more than 2.5 million people worldwide. Symptoms include weakness and numbing, pain, swallowing problems, blurred vision and diffi...
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More than 30 million people suffer from age-related macular degeneration (AMD), the most common cause of permanent vision loss among older adults. Few treatment options are available for AMD, or for j...
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Diabetes mellitus continues to be a chronic public health issue despite the availability of injectable insulin since the 1920s. Finding alternative treatments is the subject of intense research. In re...
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Fungal infections range in severity from common athlete’s foot to life-threatening illness. Treatment can be very expensive. The cost of treating systemic Candida yeast infections exceeds $31,000 pe...
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Millions of people in the U.S. suffer from chronic pain each year. Narcotic-based medications commonly are given for pain relief, but they are not always effective and can lead to addiction.Botulinum ...
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UW-Madison researchers have developed a mutant form of Gardernella where the toxin is knocked out. This non-pathogenic version of the bacteria could be developed into a safer treatment for bacterial v...
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UW-Madison researchers have developed an integrated targeted protein degrader (TPD) platform using chemically engineered endogenous platelets. The platform is constructed by grafting ubiquitin-proteas...
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UW-Madison researchers have developed new splice-switching antisense oligonucleotides (SSOs) to shift titin protein isoform production from the smaller isoform to the larger isoform, which could allev...
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UW-Madison researchers have developed lipid nanoparticles (LNPs) specifically designed to deliver gene therapies to injured CNS tissue. The LNPs can be administered intravenously, entering the CNS inj...
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UW-Madison researchers in collaboration with Medical College of Wisconsin researchers have developed longer lasting botulinum toxin light chain proteins. While the heavy chain of the protein targets t...
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UW-Madison researchers have discovered an entirely new extracellular vesicle (EV), which they have coined pyosomes, that are formed during tumor cell pyroptosis. The inventors developed a workflow (il...
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A former UW-Madison faculty member in collaboration with a professor at Marquette identified a bacillus strain that can act as a potent anti-bacterial biofilm agent.
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UW-Madison researchers have discovered new uses for macrophages produced without SIRPα. SIRPα is a ligand for the ubiquitously expressed “don’t-eat-me” signal molecule CD47. The inventors disc...
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UW-Madison researchers in collaboration with a researcher at City of Hope Cancer Center developed a combination therapy that utilizes Keytruda and a clinically approved receptor tyrosine kinase inhibi...
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UW-Madison researchers have created a “cellular hive” that addresses the shortcomings of existing immune checkpoint blockade (ICB)-based immunotherapy. In short, the inventors leverage a two-part ...
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A UW-Madison researcher and colleagues have developed methods of using probiotic bacteria engineered to express IL-22 or IFN-β, alone or in combination with an immune checkpoint therapy and/or an irr...
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Building off earlier work relating to mineral coatings, UW-Madison researchers have extended this work to FeOs to generate mineral-coated FeO microparticles (FeO MCMs). The FeO MCMs are created using ...
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The present invention relates to cold-adapted SARS-CoV-2 viruses created and being characterized by Dr. Kawaoka’s team at U. Tokyo. The researchers have passaged the isolate (SARS-CoV-2/UW-001/Human...
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UW-Madison researchers have developed a new way to select protein and cyclic peptide binders of amyloid-β (Aβ) oligomers. This innovation uses a transcription factor that the inventors previously en...
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UW-Madison researchers have developed a biocompatible alginate-based hydrogel containing Pexidartinib (PLX) loaded nanoparticles (PLX-NPs) alone or in combination with platelet conjugated aPD-1 (P-aPD...
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UW-Madison researchers have developed a combination of low dose radiation with a CAR T cell to treat solid tumors. They provided a low dose of targeted radionuclide therapy given prior to CAR T cell i...
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A UW-Madison researcher has developed a web-based atlas of cell surface target (CST) protein expression across various cancer types. This system can be used to identify understudied drug targets for t...
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UW-Madison researchers have discovered that MYDGF-knockout iNeutrophils (neutrophils produced through differentiation from pluripotent stem cells) have the ability to efficiently migrate across endoth...
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UW-Madison researchers have developed a method of using a combination of derivatives of lignin molecules to treat fungal pathogens. The researchers have studied a combination of two molecules that are...
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