UW-Madison researchers in collaboration with a researcher at City of Hope Cancer Center developed a combination therapy that utilizes Keytruda and a clinically approved receptor tyrosine kinase inhibi...
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UW-Madison researchers have created a “cellular hive” that addresses the shortcomings of existing immune checkpoint blockade (ICB)-based immunotherapy. In short, the inventors leverage a two-part ...
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A UW-Madison researcher and colleagues have developed methods of using probiotic bacteria engineered to express IL-22 or IFN-β, alone or in combination with an immune checkpoint therapy and/or an irr...
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Building off earlier work relating to mineral coatings, UW-Madison researchers have extended this work to FeOs to generate mineral-coated FeO microparticles (FeO MCMs). The FeO MCMs are created using ...
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The present invention relates to cold-adapted SARS-CoV-2 viruses created and being characterized by Dr. Kawaoka’s team at U. Tokyo. The researchers have passaged the isolate (SARS-CoV-2/UW-001/Human...
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UW-Madison researchers have developed a new way to select protein and cyclic peptide binders of amyloid-β (Aβ) oligomers. This innovation uses a transcription factor that the inventors previously en...
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UW-Madison researchers have developed a biocompatible alginate-based hydrogel containing Pexidartinib (PLX) loaded nanoparticles (PLX-NPs) alone or in combination with platelet conjugated aPD-1 (P-aPD...
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UW-Madison researchers have developed a combination of low dose radiation with a CAR T cell to treat solid tumors. They provided a low dose of targeted radionuclide therapy given prior to CAR T cell i...
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A UW-Madison researcher has developed a web-based atlas of cell surface target (CST) protein expression across various cancer types. This system can be used to identify understudied drug targets for t...
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UW-Madison researchers have discovered that MYDGF-knockout iNeutrophils (neutrophils produced through differentiation from pluripotent stem cells) have the ability to efficiently migrate across endoth...
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UW-Madison researchers have developed a method of using a combination of derivatives of lignin molecules to treat fungal pathogens. The researchers have studied a combination of two molecules that are...
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UW-Madison researchers have developed a glioblastoma cancer vaccine using primary tumor cells transfected with a genetic construct expressing a fusion of IL-7 and GM-CSF. The transfected cells are tre...
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UW-Madison researchers have discovered two peptides, HLTF;zf-C3HC4 and RO52;zf-C3HC4 (hereafter referred to as the HLTF peptide and the RO52 peptide) which, when tethered to a protein induce degradati...
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A UW researcher has developed a method of supplementing the diet of infants to prevent the development of type 1 diabetes in children. This researcher also developed a synthetic insulin analog that pr...
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UW-Madison researchers have developed a protein degrader that shuttles targeted extracellular protein into the lysosome using a cyclic peptide that binds to a cellular receptor attached to a binding m...
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UW-Madison researchers have developed a novel photoreceptor specific promoter-enhancer construct that they call “IMPG2 PE1”, which is based on two distinct regulatory sequences of the human Interp...
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A UW-Madison researcher has engineered Lactobacillus reuteri (L. reuteri VPL1014) to express a recombinant gene from the chromosome or plasmid. The gene product can be rodent-, monkey-, or human-deriv...
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UW-Madison researchers have developed a mouse model (PPCD1-Delta 40) for Posterior Polymorphous Corneal Dystrophy (PPCD).They have also developed second mouse model (see P250382US01 below).
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UW-Madison researchers have developed a mouse model (PPCD1) for Posterior Polymorphous Corneal Dystrophy (PPCD). They have also developed second mouse model (see P250382US02 below).
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A UW-Madison researcher has engineered Lactobacillus reuteri (L. Reuteri VPL1014) to encode a native antirepressor protein whose expression is placed under the control of an inducible promoter along w...
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UW-Madison researchers have developed an AI-based method for designing humanized CAR sequences. Using this method, they developed two novel humanized CD19 sequences that can be used for production of ...
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UW-Madison researchers have developed a method for stopping seizures in patients suffering from acquired epilepsy. The treatment strategy utilizes Tofacitinib, a JAK/STAT inhibitor currently prescribe...
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A UW-Madison researcher has developed an oral combination therapy for treating fibrolamellar carcinoma (FLC) that utilizes a CDK7 inhibitor and a CDK9 inhibitor. The researcher created a cancer cell l...
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UW-Madison researchers in collaboration with researchers at the Oak Ridge National Laboratory have developed chelated antimony (Sb) that can be used for targeted Auger radiotherapy. While 119Sb has be...
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UW-Madison researchers have developed improved methods for optimizing the characteristics of salivary gland-derived mesenchymal stromal cells (MSCs) for therapeutic administration.The inventors have d...
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