Wisconsin Alumni Research Foundation

Technology

Transferrin-Based Lysosome Targeting Degraders

UW researchers have developed a novel means of degrading extracellular proteins as a potential cancer treatment. The researchers recognized that transferrin is a protein ligand that carries iron into ...
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Weiping Tang, Yaxian Zhou | P210432US02

Technology

CARDIAC FIBROBLAST DERIVED EXTRACELLULAR MATRIX

UW-Madison researchers have discovered a novel marker in cardiac fibroblasts and myofibroblasts that reliably predicts extracellular matrix production in cultured cardiac fibroblasts. Sushi Domain Con...
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Eric Schmuck, Amish Raval, Sushmita Roy, Tianhua Zhou | P210363US02

Technology

Turbinmicin Compounds And Compositions As Potent Antifungal Agents

The present invention from UW Madison inventors is a set of analogs of turbinmicin that show similar efficacy but are more soluble than the parent molecule. The parent molecule proved to be fairly ins...
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Timothy Bugni, Weiping Tang, Le Guo, Changgui Zhao, Fan Zhang, Douglas Braun, David Andes, Miao Zhao, Jenna Fossen | P200353WO01

Technology

Nonviral Generation of Genome-Edited CAR T Cells

Use of viral vectors for chimeric antigen receptor (CAR) T cell manufacturing constitutes a bottleneck in the supply chain for biomanufacturing and can be problematic due to: (1) batch-to-batch variab...
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Krishanu Saha, Christian Capitini, Katherine Mueller, Nicole Piscopo, Amritava Saha, Matthew Forsberg, Louise Saraspe | P200184US02

Technology

NEUTRALIZING VACCINES AGAINST HUMAN CORONAVIRUS

The present invention provides both QuilA-loaded chitosan (QAC)-encapsulated DNA vaccine compositions and viral vaccine compositions that encode a SARs-CoV-2 spike (S) protein, a SARs-CoV-2 nucleocaps...
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Adel Talaat, Shaswath Chandrasekar | P210042US02

Technology

Anti-Apoptotic Vector And Method Of Using The Same

UW Madison researchers' present invention provides vectors for delivery of an anti-apoptotic therapy. The vectors include a phosphoglycerate kinase (Pgk) promoter operably connected to a polynucleotid...
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Robert Nickells, Gillian McLellan, Ryan Donahue | P210046WO01

WARF