Wisconsin Alumni Research Foundation

Technology

NEUTRALIZING VACCINES AGAINST HUMAN CORONAVIRUS

The present invention provides both QuilA-loaded chitosan (QAC)-encapsulated DNA vaccine compositions and viral vaccine compositions that encode a SARs-CoV-2 spike (S) protein, a SARs-CoV-2 nucleocaps...
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Adel Talaat, Shaswath Chandrasekar | P210042US02

Technology

Anti-Apoptotic Vector And Method Of Using The Same

UW Madison researchers' present invention provides vectors for delivery of an anti-apoptotic therapy. The vectors include a phosphoglycerate kinase (Pgk) promoter operably connected to a polynucleotid...
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Robert Nickells, Gillian McLellan, Ryan Donahue | P210046WO01

Technology

Inhibitors Of Bacterial Pasta Kinases

Biochemically active PASTA kinase inhibitors which exploit subtle structural differences between human kinases and bacterial PASTA kinases to improve specificity and inhibitor activity.
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Robert Striker, Nathan Wlodarchak, John Feltenberger, Jennifer Golden | P180315US02

Technology

Nonviral Generation Of Genome Chimeric Antigen Receptor T Cells

Described herein are non-viral, ex vivo methods of site-specifically inserting a transgenecontaining a chimeric antigen receptor (CAR) gene into a T cell genome by introducing into apopulation of unmo...
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Krishanu Saha, Christian Capitini, Katherine Mueller, Nicole Piscopo, Amritava Saha, Matthew Forsberg, Louise Saraspe | P200184US02

Technology

CHO Cell Line Expressing HERG-1 Potassium Channels

HERG-1 (human ether-a-go-go-related gene) potassium channels mediate repolarization of cardiac action potentials. Loss of function mutations in hERG-1 can result in long QT syndrome, an inherited diso...
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Gail Robertson, Barry Ganetzky, Jeffrey Warmke, Matthew Trudeau, Samuel Breit, Terence Campbell, Bruce Walker, Stella Valenzuela | P00082US

Technology

COVID-19 Vaccine

Provided herein are antigenic peptides comprising the SARS-CoV-2 spike protein receptor binding domain (CRBD) polypeptide or portions thereof, linked to a non-catalytic, non­toxic tetanus toxin varia...
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Joseph Barbieri, Eric Johnson, Sabine Pellett, William Tepp, Amanda Przedpelski | P200268US03

WARF