Drug Discovery & Development
Knockout of GFAP In the Mouse (Model tm1Mes)
Inventors: Albee Messing, Maureen McCall
UW-Madison researchers have developed a GFAP knockout mouse model, designated tm1Mes, that has been engineered to have an internal deletion of the Gfap gene that renders it completely non-functional. The mice are viable with no overt phenotype except following various types of injuries.