Bacterial Genomic Libraries from Alaskan Soils (AK 22 and 23)
Inventors: Jo Handelsman, Lynn Williamson
The Wisconsin Alumni Research Foundation (WARF) is seeking commercial partners interested in two libraries of bacterial genomic DNA isolated directly from non-permafrost soils in an extremely cold and phosphorus-poor environment.
Cultured microorganisms produce an extraordinary array of structurally diverse and valuable organic compounds; however, microbes that can be cultured using standard techniques represent only a small fraction of the microbial diversity present in any natural environment. To more fully exploit this vast reservoir, large amounts of microbial DNA can be isolated directly from soil and screened for useful genes and gene products.
UW-Madison researchers have compiled two libraries of bacterial genomic DNA isolated directly from non-permafrost soils in the floodplain of the Tanana River, an extremely cold and phosphorus-poor environment near Fairbanks, Alaska. This collection of genomic DNA complements a collection of more than 1,000 bacterial cultures and 19 additional libraries of bacterial genomic DNA isolated from the same Alaskan soils.
- Provides additional, potentially valuable sources of new genes, antibiotics, metabolic processes and cold-adapted enzymes for food processing, medical and industrial applications
- Microorganisms adapted to exceptionally harsh environments are a promising source of novel metabolic processes, antibiotics, enzymes and other proteins.
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