Wisconsin Alumni Research Foundation

Drug Discovery & Development
Drug Discovery Development
Mouse Strains and Cells Useful to Investigate Tissue-Specific Roles of Stearoyl-CoA Desaturase Isoforms
WARF: P08224US

Inventors: James Ntambi

The Wisconsin Alumni Research Foundation (WARF) is seeking commercial partners interested in developing materials useful for the study of SCDs and their tissue-specific roles.
Stearoyl-CoA desaturase (SCD) is the rate-limiting enzyme in the biosynthesis of monounsaturated fatty acids. SCDs may influence the development of diseases such as obesity, atherosclerosis and diabetes.
The Invention
A UW–Madison researcher has developed several mouse strains and cells useful in the study of SCDs.  To understand the tissue-specific role of SCD1 and other SCD isoforms in disorders such as obesity, diabetes, cancer, inflammation, atherosclerosis and metabolism, the researcher generated mice with tissue-specific knockouts of SCDs.  He also developed transgenic mice in which SCDs can be overexpressed in specific tissues.
  • Studying SCDs and their tissue-specific roles 
Key Benefits
  • Provides new tools for investigating the roles of SCD isoforms in various tissues
Additional Information
For current licensing status, please contact Rafael Diaz at [javascript protected email address] or 608-960-9847