Drug Discovery & Development
Mouse Strains and Cells Useful to Investigate Tissue-Specific Roles of Stearoyl-CoA Desaturase Isoforms
Inventors: James Ntambi
The Wisconsin Alumni Research Foundation (WARF) is seeking commercial partners interested in developing materials useful for the study of SCDs and their tissue-specific roles.
Stearoyl-CoA desaturase (SCD) is the rate-limiting enzyme in the biosynthesis of monounsaturated fatty acids. SCDs may influence the development of diseases such as obesity, atherosclerosis and diabetes.
A UW–Madison researcher has developed several mouse strains and cells useful in the study of SCDs. To understand the tissue-specific role of SCD1 and other SCD isoforms in disorders such as obesity, diabetes, cancer, inflammation, atherosclerosis and metabolism, the researcher generated mice with tissue-specific knockouts of SCDs. He also developed transgenic mice in which SCDs can be overexpressed in specific tissues.
- Studying SCDs and their tissue-specific roles
- Provides new tools for investigating the roles of SCD isoforms in various tissues