Wisconsin Alumni Research Foundation

Drug Discovery & Development
Drug Discovery Development
Mouse Model of Alexander Disease (Model B6.129S7 (Cg) Gfap tm2Mes)
WARF: P220167US01

Inventors: Albee Messing, Tracy Hagemann

The Invention
UW-Madison researchers have developed a mouse model of Alexander disease, designated B6.129S7 (Cg) Gfap tm2Mes, that was engineered as a knock-in of the R236H point mutation in the Gfap gene; this is a missense mutation (‘targeted mutation 2’) homologous to those found in humans, in a B6 mouse background. This is the same mutation as in FVB.129S7 (Cg) Gfap tm2Mes (P220165) but that one is in an FVB background.
For current licensing status, please contact Jennifer Gottwald at [javascript protected email address] or 608-960-9854