Wisconsin Alumni Research Foundation

Therapeutics & Vaccines
Therapeutics Vaccines
Engineered Botulinum Neurotoxin C1 With Selective Substrate Specificity
WARF: P100145US02

Inventors: Meyer Jackson, Dongsheng Wang

The Invention
An isolated polypeptide comprising a botulinum neurotoxin C1 light chain having a modified amino acid sequence relative to the sequence of a wild-type botulinum neurotoxin C1 light chain is disclosed. The modified botulinum neurotoxin C1 light chain is capable of selectively cleaving syntaxin protein, but has substantially reduced or no activity against SNAP-25 as compared to wild type botulinum neurotoxin C1 light chain, and is thus useful as a research tool and in medical treatment.
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