Therapeutics & Vaccines
19,26,27-trinor-1alpha,25-dihydroxyvitamin D3 Compounds
Inventors: Hector DeLuca, Lori Plum, Pawel Grzywacz, Margaret Clagett-Dame
This invention relates to vitamin D compounds, and more particularly to 19,26,27-trinor-1α,25-dihydroxyvitamin D3 compounds such as 2α-methyl-19,26,27-trinor-(20S)-1α,25-dihydroxyvitamin D3 (“P10”), 2β-methyl-19,26,27-trinor-(20S)-1α,25-dihydroxyvitamin D3 (“T-74”), and 2-methylene-19,26,27-trinor-(20S)-1α, 25-dihydroxyvitamin D3 (“BM”), and to pharmaceutical formulations that include these compounds or mixtures thereof. The invention also relates to the use of P10, T-74, and BM, salts thereof, and mixtures thereof in the preparation of medicaments for use in treating various diseases.
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