Therapeutics & Vaccines
Synthesis And Biological Activity Of 2-Methylene Analogs Of Calcitriol And Related Compounds
Inventors: Hector DeLuca, Lori Plum, Rafal Sicinski, Izabela Sibilska-Kaminski
Disclosed are 2-methylene analogs of vitamin D3 and related compounds, their biological activities, and various pharmaceutical uses for these analogs. Particularly disclosed are 1α-hydroxy-2-methylene-vitamin D3, (20S)-1α-hydroxy-2-methylene-vitamin D3, and (5E)-1α,25-dihydroxy-2-methylene-vitamin D3, their biological activities, and various pharmaceutical uses for these compounds including methods of treating and/or preventing bone diseases and disorders.