Therapeutics & Vaccines
IDO Activity As A Marker Of Tumor Immune Escape And IDO Inhibitors As A Means Of Enhancing T Cells Response To Antigen Specific Vaccine
Inventors: Douglas McNeel, Christopher Zahm, Laura Johnson
The present invention from UW Madison researchers provides compositions and methods of treating prostate cancer using a combination of a DNA vaccine, PD-1 inhibitor and an IDO inhibitor. Further, methods of measuring IDO activity as a way to identify a subpopulation of subjects with prostate cancer that may benefits from the treatment methods described herein are provided.
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