Wisconsin Alumni Research Foundation

Therapeutics & Vaccines
Therapeutics Vaccines
Vectors For Eliciting Immune Responses To Non-Dominant Epitopes In The Hemagglutinin (Ha) Protein
WARF: P190028US02

Inventors: Yoshihiro Kawaoka, Gabriele Neumann, Huihui Kong

The Invention
Methods of preparing influenza viruses having altered immunodominant epitopes in HA, e.g., having one or more residues in one or more of antigenic sites A-E in HA altered, and viral vectors, e.g., influenza virus VLPs or non-influenza viruses or VLPs thereof expressing or having influenza HAs with altered immunogenicity as a result of altered immunodominant epitopes therein are provided.
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