Wisconsin Alumni Research Foundation

Therapeutics & Vaccines
Therapeutics Vaccines
Vaccines Comprising Mutant Attenuated Influenza Viruses
WARF: P100251US02

Inventors: Yoshihiro Kawaoka, Shinji Watanabe, Tokiko Watanabe

The Invention
The invention provides a vaccine comprising an effective amount of an isolated recombinant influenza virus comprising a mutant M gene segment that is mutated so that upon viral replication the mutant M gene expresses a functional M1 protein and a mutant M2 protein with a deletion of the cytoplasmic tail and either lacking a transmembrane domain or having a mutated transmembrane domain.
For current licensing status, please contact Jennifer Gottwald at [javascript protected email address] or 608-960-9854