Wisconsin Alumni Research Foundation

Therapeutics & Vaccines
Therapeutics Vaccines
Modified Clostridial Neurotoxins As Vaccines And Conjugate Vaccine Platforms
WARF: P190179US02

Inventors: Eric Johnson, Sabine Pellett, William Tepp, Joseph Barbieri, Amanda Przedpelski

The Invention
Provided herein are engineered non-catalytic, non-toxic tetanus toxin variants and methods of using such engineered tetanus toxin variants as low dose, protective vaccines that are non-toxic and more potent than their respective chemically inactivated toxoids. In addition, provided herein are conjugate vaccine carriers comprising engineered tetanus toxin variants and methods of using such conjugate vaccines to elicit T-cell dependent immune memory responses which can target a broad spectrum of microbial pathogens as a single vaccine.
Additional Information
For More Information About the Inventors
For current licensing status, please contact Rafael Diaz at [javascript protected email address] or 608-960-9847