Therapeutics & Vaccines
Recombinant Influenza Viruses With Stabilized Ha For Replication In Eggs
Inventors: Yoshihiro Kawaoka, Shinya Yamada, Shiho Chiba
Modified influenza virus neuraminidases are described herein that improve viral replication, thus improving the yield of vaccine viruses. Expression of such modified neuraminidases by influenza virus may also stabilize co-expressed hemagglutinins so that the hemagglutinins do not undergo mutation or decrease the need for HA binding to cells.