Therapeutics & Vaccines
Inventors: Joseph Barbieri, Eric Johnson, Sabine Pellett, William Tepp, Amanda Przedpelski
Provided herein are antigenic peptides comprising the SARS-CoV-2 spike protein receptor binding domain (CRBD) polypeptide or portions thereof, linked to a non-catalytic, nontoxic tetanus toxin variant (i.e., a modified tetanus toxin or "MTT") and vaccine compositions comprising the same. In addition, provided herein are methods for making and using CRBDMTT fusion proteins as immunogenic agents.
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