Therapeutics & Vaccines
HYDROGEL COMPOSITIONS COMPRISING GASDERMIN D AND AN ESCRT INHIBITOR AND METHODS OF USE THEREOF
Inventors: Quanyin Hu, Zhaoting Li
UW-Madison researchers have developed a novel approach for enhancing pyroptosis, which could prove beneficial in treating cancer. The inventors combine intracellular delivery of gasdermin with a small molecule that interferes with membrane repair in a single hydrogel nanoparticle. The gasdermin is delivered using a bacterial based vector (VNP-GD) and a calcium chelator (EI) is adhered to a nanoparticle (EI-NP). Calcium chelation blocks influx-triggered ESCRT III-dependent membrane repair. A biodegradable hydrogel matrix is used as a carrier to deliver and sustainably release the VNP-GD and EI-NP.
- Platform delivery method
- Compatible with a range of therapeutic modalities
- Sustainable release