Therapeutics & Vaccines
MODULAR DENDRON MICELLES FOR COMBINATION IMMUNOTHERAPY
Inventors: Seungpyo Hong, Deric Wheeler
UW-Madison researchers have developed a nanoparticle-based platform comprising targeting agents (i.e., tumor selective peptides) and active agents (e.g., immuno- and chemo-drugs). The nanoparticles comprise hyperbranched dendrons, linear hydrophobic polymers, and a polyethylene glycol (PEG) corona. When functionalized, these materials self-assemble into immunotherapeutic dendron-micelles, which can be administered as a pharmaceutical formulation. Given their adaptability, the dendrimer-micelle nanoparticles could be further functionalized to existing radiation therapy agents, further enhancing their functionality.